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Pharmacology

Pharmacology. By: Kunwal Nasrullah and Badrul Islam Dr. Mark G. Klang Memorial Sloan Kettering Cancer Center; Harlem Children ’ s Center. What is Pharmacology?. Pharmacology is the study of how chemical substances interact with living systems. This field includes:

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Pharmacology

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  1. Pharmacology By: Kunwal Nasrullah and Badrul Islam Dr. Mark G. Klang Memorial Sloan Kettering Cancer Center; Harlem Children’s Center

  2. What is Pharmacology? • Pharmacology is the study of how chemical substances interact with living systems. • This field includes: • Drug composition, interactions, toxicology, and therapy

  3. Pharmacology (Contd.) • Pharmacologists study four aspects of drugs: • Absorption-How is the medicine absorbed? • Distribution- How is the medicine spread throughout the body? • Metabolism-Is the medicine converted into other chemicals in the body? • Excretion-How is the medicine eliminated from the body?

  4. Basic Principles of Pharmacology • Absorption (Pharmaceutical Phase)- • Through the skin, intestinal tract, intravenously, mouth, or inhalation (nasal mucosa) • Organ systems involved: • Circulatory • Respiratory • Excretory • Digestive

  5. Basic Principles of Pharmacology (Contd.) • Distribution • Dependent upon tissue permeability, blood flow, perfusion rate of the tissue, drug binding of plasma proteins and tissues.

  6. Basic Principles (Contd.) • Metabolism • Chemical conversion of medication inside the body into substances. • Things that pharmacologists consider: • The activity of by-products. (Toxicity) • Almost all drugs are xenobiotics.

  7. Basic Principles (Contd.) • Excretion Elimination of medicine (through urine, bile, breath, skin).

  8. Pharmacological Devices • HPLC (High Performance Liquid Chromatography) • pH meter • UV Spectrofometer • Refractometer

  9. Future Research • Examination of drugs in health foods (protein shakes, vitamins, etc.). • Testing compatibility and stability of generic drugs aimed at treating cancer and its side affects with Dr. Klang.

  10. References • http://xnet.rrc.mb.ca/davidb/pharmacology.htm • http://en.wikipedia.org/wiki/Pharmacology • http://www.thebody.com/tpan/winter05/images/abcs_figure1.jpghttp://www.thebody.com/tpan/winter05/images/abcs_figure1.jpg • http://web.vet.cornell.edu/public/pharmacokinetics/excretion/enterohepatic.gif

  11. Acknowledgments • Dr. Mark G. Klang • Harlem Children Society and Dr. Sat Bhattcharya • Sloan Kettering Cancer Center

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