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Basic Echocardiography Case Studies

Basic Echocardiography Case Studies. Wendy Blount, DVM Nacogdoches TX. Trip. Signalment 2 year old castrated male border collie Chief Complaint/History Productive Cough, weight loss for 2 months Breathing hard for a 2 days Energy good; did well in agility 4 days ago

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Basic Echocardiography Case Studies

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  1. Basic EchocardiographyCase Studies Wendy Blount, DVM Nacogdoches TX

  2. Trip Signalment • 2 year old castrated male border collie Chief Complaint/History • Productive Cough, weight loss for 2 months • Breathing hard for a 2 days • Energy good; did well in agility 4 days ago • Owner thinks has had lifelong PU-PD • Has wanted to be in AC this summer – unlike last summer when he enjoyed being outside

  3. Trip Exam • T 102.2, P 168, R 42, CRT 3 sec, BCS 2.5, BP 100 • 3 murmurs: • To-and-fro murmur, 3/6, PMI left base • Holosystolic murmur 3/6 over rest of chest • 2/6 ejection murmur PMI Carotid • Bounding pulses, notable in small arteries • Precordial – exaggerated left apical heave • Lung sounds clear

  4. Trip Differential Diagnoses • Aortic endocarditis • SAS with aortic regurgitation • Mitral regurgitation (endocarditis?) Diagnostic Plan • Thoracic radiographs • EKG • Echocardiography

  5. Trip EKG • Normal sinus rhythm for 10 minutes Thoracic Radiographs • Interstitial pattern caudal lung fields • Vertebral heart score 10.5

  6. Trip - Echo Short Axis – LV Apex (video) • No abnormalities noted Short Axis – LV PM • LVIDD – 57.3 (n 31.3-34) • IVSTS – 15.5 mm (n 12.6-13.7) • LVIDS – 41.1 mm (18.8-20.7) • FS = (57.3-41.1)/57.3 = 28% (n 30-46%) • EF = 54% (n >70%)

  7. Trip - Echo Short Axis – MV • EPSS – 8 mm (n 0-6) Short Axis – Ao/RVOT • AoS – 20.2 (normal) • LAD – 27.8 (n 19.0-20.5) • LA/Ao – 27.8/20.2 = 1.38 (n 0.8-1.3) • Aortic valve leaflets are hyperechoic

  8. Trip - Echo Short Axis – PA • No abnormalities noted Long Axis – 4 Chamber • LA appeared mildly enlarged • IVS bowed anteriorly toward RV • No evidence of mitral encodarditis or endocardiosis

  9. Trip - Echo Long Axis – LVOT • Hyperechoic thickened mitral valve leaflets Diagnosis • Aortic endocarditis Therapeutic Plan • Elected euthanasia due to poor prognosis

  10. Maximus 18 month old male Boxer Chief Complaint • Drastic and rapid weight loss • Not eating well • Coughing up blood tinged fluid since yesterday Exam • Similar to Trip, except temp 103.8 • And BCS 2

  11. Maximus Diagnostics • Thoracic Radiographs • Severe perihilar and interstitial edema • LA enlargement • VHS 12.5 • Pulmonary lobar veins 2X arteries • EKG • Normal sinus rhythm • P wave 0.5 mV tall x 0.06 msec • QRS complex tall 25-30 mV x 0.05 msec • LA and LV enlargement

  12. Maximus Diagnostics • Blood culture • negative (2 samples 2 hours apart) • Urine culture • Enterobacter susceptible to all • CBC • neutrophilia 23,100/ul • Mild anemia – PCV 35.5%

  13. Maximus Diagnostics • General Health Profile, electrolytes • BUN – 55 (n 10-29) • ALT – 225 (n 10-120) • Albumin – 2.2 (n 2.3-3.7) • Urinalysis • USG – 1.045 • WBC 7-10/hpf, rare bacteria seen

  14. Maximus Treatment (58 lbs, BCS 2, RR 66) • Antibiotics • IV - ampicillin 750 mg TID, Baytril 150 mg BID x 3 days • IM – ampicillin 750 mg BID, Baytril 150 mg x 3 days • PO – ampicillin 750 mg BID, Baytril 136 mg PO for life • Furosemide • 100 mg IV TID the first day - RR down to 28 • Then 75 mg PO BID • Enalapril – 15 mg PO BID

  15. Maximus Treatment – Day 3 – RR 30, eating well • Chest x-rays • Pulmonary edema much improved, but mild amount still present • Furosemide - 75 mg PO BID • Enalapril – 15 mg PO BID • Added Spironolactone – 25 mg PO BID

  16. Maximus Diagnostics – Day 5 – RR 36, BP 150 • Chest x-rays - No change • BUN – 43 • Electrolytes - normal Treatment – Day 5 • Furosemide - 75 mg PO BID • Enalapril – 15 mg PO BID • Spironolactone – increased to 50 mg PO BID • Added Hydralazine – 12.5 mg PO BID

  17. Maximus Diagnostics – Day 10 RR 30, BP 135, Wt 61.8, Temp 103 • Chest x-rays – perihilar edema resolved • BUN – 11, albumin 2.3 • Electrolytes – normal • CBC – neutrophilia 23,000/ul Continued this treatment for the rest of Max’s life – 3 months

  18. Valvular Endocarditis Clinical Features • Present for FUO, weight loss or heart failure • Aortic much more common than mitral • Dogs much more common than cats • Many bacteria including Bartonella • Breed predisposition • Rottweiler, Boxer, Golden retriever • Newfoundland, German shepard

  19. Valvular Endocarditis Clinical Features • Abnormal valve + bacteremia = endocarditis • Bacteremia caused routinely by: • Dental cleaning • Brushing your teeth (chewing) • Constipation, any GI illness • defecation • Urinary catheterization • infection

  20. Valvular Endocarditis ECG abnormalities • Tall, wide P wave (LA enlargement) • Tall R wave (LV enlargement) • Ventricular arrhythmias common (handout) • Treat if multiform of >30 per minute • Class I or III antiarrhythmic • Sotalol 2-3 mg/kg PO BID Thoracic radiographs • Left heart failure

  21. Valvular Endocarditis Echocardiographic abnormalities • Thickened, hyperechoic valves • Vegetation may flop around • MV in diastole, AV in systole • Variable LV dilation (more with time) • FS normal to low normal until myocardial failure • MV endocarditis can be difficult to distinguish from MV endocardiosis • Endocarditis dogs are systemically ill

  22. Valvular Endocarditis Treatment • Based on urine and blood culture and sensitivity, Bartonella PCR • Antibiotics • IV 3-5 days – broad spectrum until culture results • SC/IM 3-5 days • Then PO long term – often for life • Treat Heart failure (severe) • Treat ventricular arrhythmia if present • Watch for and treat bacterial embolization of abdominal organs, skin, IVDiscs, CNS, joints, etc. • Watch for and treat immune complex disease

  23. Valvular Endocarditis Prognosis • <20% survival • Antibiotic therapy often required for life • Median survival is 6 days from diagnosis for aortic endocarditis • Survival is longer for mitral endocarditis • LHF due to MR not as severe as AoR

  24. Ike Signalment • 7 year old castrated male Persian cat Chief Complaint • Recurring anemia • Episodes of weakness, anorexia, dullness and salivation • Constipation often associated with episodes • Tremendous hair loss and 2 lb weight loss over 6 months

  25. Ike Exam – T 100.3, P 180, R 40, BP 135 • Fleas++++ • Gallop rhythm, followed by normal heart sounds, followed by 2/6 systolic murmur • Hepatomegaly and mild to moderate ascites • Jugular vein distension • Did not do hepatojugular reflux test • Tongue protrudes and tip is dry • Breathes with mouth open when stressed

  26. Ike Diagnostics • CBC – normal • FeLV/FIV – negative • GHP/electrolytes – • ALT – 218 (n 10-100) • Bili – 0.3 (high normal) • Albumin 1.7 (n 2.3-3.4) • K – 2.5 (n 2.9-4.2)

  27. Ike Diagnostics • Chest x-rays • Elevated trachea • Generalized cardiomegaly – VHS 9 • Distended caudal vena cava • Hepatomegaly • Ascites

  28. Ike Diagnostics • Diagnosis - Right heart failure with cardiomegaly • DDx – cardiomegaly • Diaphragmatic hernia • pericardial effusion • heart enlargement • HCM, DCM, RCM • VSD • Valvular disease • Hypoalbuminemia/liver disease may be contributing to ascites

  29. Ike DDx Hypoalbuminemia • Liver disease • PLN • PLE unlikely with no clinical signs • Sequestration in ascites

  30. Ike Initial Treatment • No echo done because Ike became dyspneic after chest rads • Furosemide 5 mg PO BID (wt 5 lbs 7 oz) • Potassium gluconate 2 mEq PO SID • Metronidazole 625 mg PO SID x 2 weeks

  31. Ike Recheck Scheduled for 1 week • Echocardiogram • Electrolytes • Abdominal US • UPC • bile acids • Fluid analysis if ascites fails to resolve

  32. Ike Recheck – 1 week - Exam • Ike tremendously improved • Weight gain of 5 ounces • Ascites has resolved • Hepatomegaly no longer present • P 160, RR 28, BP 110 • Haircoat seems improved • 2/6 systolic murmur loudest at the sternum • No open mouth breathing or inc RR when stressed

  33. Ike Recheck – 1 week - Diagnostics • Electrolytes – K 2.7 • Albumin - 2.4 (normal) • ALT - 134 (n 10-100) • Bili - 0.3 • UPC – 0.5 • Bile Acids (fasting) - 157

  34. Ike - Echo Short Axis – LV Apex • Mild pericardial effusion Short Axis – LV PM • Mild pericardial effusion • LV subjectively thick • No evidence of pericardial hernia

  35. Ike - Echo Short Axis – LV PM • IVSTD – 10.2 (n 3-6) • LVIDD – 14.1 (n 10-21) • LVPWD – 6.95 (n 3-6) • IVSTS – 14.85 (4-9) • LVIDS – 3.5 (n 4-10) • LVPWS – 9.6 (n 4-11) • FS – (14.1-3.5)/14.1 = 74.5% EF = 98%

  36. Ike - Echo Short Axis – LV MV • EPSS – 2 mm Short Axis – LA/RVOT • RVOT looks subjectively enlarged • LA and LA normal • LA/Ao = 11.1/8.8 = 1.26 (normal)

  37. Ike - Echo Short Axis – PA • Enlarged main pulmonary artery • RV enlarged Long Axis – 4 Chamber • No apparent enlargement of LA • LV thickened

  38. Ike - Echo Long Axis – LVOT • No apparent enlargement of LA • LV thickened

  39. Ike - Echo Abdominal US • No fluid present in the abdomen • Main bile duct tortuous • Pancreas normal • Did not do liver aspirate because Ike would not tolerate it without general anesthesia

  40. Ike - Echo Treatment - Update • Finish metronidazole, then start milk thistle • Increase Kgluconate to 2 mEq PO BID • Continue furosemide 5 mg PO BID • Add enalapril 1.25 mg PO SID • Recheck BUN/lytes 5 days • If OK, inrease to BID • Recheck BUN/lytes 5 days • Laxatone PRN for constipation • Recheck echo, chest rads in 6 months or sooner if RR > 40 at rest • Ike died acutely just prior to his 6 month recheck

  41. Pericardial Effusion Clinical Features • DDx • Pericarditis • Chronic CHF • Blood – left atrial tear, HSA, coagulopathy • Pericardial cyst • Idiopathic • 50% are neoplasia – carefully look at RA • ECG – electrical alternans

  42. Pericardial Effusion Echocardiographic Abnormalities • Careful not to confuse pericardial fat with pericardial effusion • Look at relative echogenicity • Careful not to confuse normal anechoic structures with pericardial effusion • Descending aorta • Enlarged left auricle

  43. Pericardial Effusion Echocardiographic Abnormalities • Careful to distinguish pericardial from pleural effusion • Pericardium not visualized with pleural effusion • Collapsed lung lobes may be seen with pleural effusion (look like liver in US) • Careful not to confuse with liver in a peritineopericardial diaphragmatic hernia • Heart may swing back & forth in the pericardium

  44. Pericardial Effusion Echocardiographic Abnormalities • Cardiac tamponade • Compression of RV • Diastolic collapse of RV • IVS may be flattened with paradoxical motion • Pericardiocentesis is imperative • Aggressive diuresis will reduce preload • Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

  45. Pericardial Effusion Video Pericardial Effusion Video Pleural Effusion Video Consolidated Lung Lobe Video Normal thorax Video Mediastinal Mass

  46. Hank Signalment • 10 week old male schnauzer Chief Complaint • Loud heart murmur heard on examination for routine vaccinations • Suspect congenital heart defect

  47. Hank Exam • mm pink, CRT 2 sec • 4/6 ejection murmur loudest at left heart base • Mild superficial pyoderma

  48. Hank Exam • mm pink, CRT 2 sec • 4/6 ejection murmur loudest at left heart base • Mild superficial pyoderma

  49. Hank Initial Differential Diagnoses • Pulmonic stenosis • Aortic Stenosis Initial Diagnostic Plan • Chest x-rays • EKG • Echocardiogram

  50. Hank Thoracic radiographs • Dorsally elevated trachea • Vertebral heart score 9.5 • Right heart enlargement • Right auricular/atrial enlargement • Distended caudal vena cava • Bulge at main pulmonary artery

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