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This study by Ricciardi et al. in Circulation 2001 highlights the association between MRI hyperenhancement and myonecrosis following PCI, emphasizing the importance of achieving TIMI 3 flow after stenting. Elevated CK-MB levels and higher HE mass were significant factors post-PCI. Impaired TMPG correlated with MRI hyperenhancement, suggesting a link to larger infarct sizes. Insights from Ramondo et al. in Catheter Cardiovasc Interv 2004 further underscore the significance of TIMI Grade 3 flow pre-PCI and the decline in post-stent TMPG as predictors of adverse outcomes.
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MRI Hyperenhancement is Associated with Myonecrosis Following PCI All Patients Have TIMI 3 Flow at Completion of Stenting Ricciardi M et al, Circulation 2001: 103: 2780-2783.
CK-MB p=0.01 4 50 HE mass p=0.04 40 3 30 2 20 1 10 0 0 No Yes Decline in post-stent TMPG Impaired TMPG is Associated with MRI Hyperenhancement; A Decline in TMPG after Stenting is Associated with Larger Infarct Sizes = Ramondo et al,Catheter Cardiovasc Interv 2004;61:222–226. All patients had normal epicardial TIMI Grade 3 Flow before PCI 12 of 14 patients had normal TMPG 3 before PCI Only 7 of 14 had normal TMPG 3 after PCI HE mass (gm) CK-MB (ng/dL) Ricciardi, Gibson et al, CCD 2004
