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B.Sc: Biology / Medical Analysis / Jor. M.Sc.: Medical Microbiology / Jor.

Prof. Mamdoh Harahsha. B.Sc: Biology / Medical Analysis / Jor. M.Sc.: Medical Microbiology / Jor. Ph.D.: Medical Virology & Serology / UK. GENERAL PROPERTIES AND CLASSIFICATIONS. INTRODUCTION. Small Dependent on living cells Genome Have receptor-binding protein. Virus. Bacterium.

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B.Sc: Biology / Medical Analysis / Jor. M.Sc.: Medical Microbiology / Jor.

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  1. Prof. Mamdoh Harahsha • B.Sc: Biology / Medical Analysis / Jor. • M.Sc.: Medical Microbiology / Jor. • Ph.D.: Medical Virology & Serology / UK

  2. GENERAL PROPERTIES AND CLASSIFICATIONS

  3. INTRODUCTION • Small • Dependent on living cells • Genome • Have receptor-binding protein

  4. Virus Bacterium Animalcell Animal cell nucleus 0.25 m Comparing the size of a virus, a bacterium, and an animal cell

  5. Size of viruses

  6. Basic components of viruses Virion (Intact virus): • Capsid (capsomeres) • Nucleic acid Both  Nucleocapsid # Envelope

  7. Influenza virus

  8. Virus symmetry (Nucleocapsid) • Icosahedral • Helical • Complex

  9. Capsid and Capsomeres

  10. Helical

  11. Icosahedral

  12. Complex

  13. Electron Microscopy

  14. Virus genomes • # All DNA viruses ds EXCEPT Parvoviridae • # All RNA viruses ss EXCEPT Reoviridae • # Positive & Negative stranded RNA • # Exons & introns

  15. Virus genome & transcriptional maps DNA viruses • Herpes & Poxvirus 150 genes  No splicing (Large No. of genes) • Adenovirus 30 genes  Viral splicing • Parvovirus Few genes  Viral splicing

  16. RNA viruses • Poliovirus: +ve ssRNA • Rabies: -ve ssRNA • Coronavirus: +ve ssRNA

  17. Classification of Viruses • NA: DNA OR RNA • Number of strands of NA: ds or ss, • Forms: Linear, Circular, Continuous (or circular with breaks as in HBV), or Segmented • Polarity • Symmetry of NA • Envelope

  18. Nomenclature of viruses • Family: --- viridae (Adenoviridiae) • Subfamily --- Virinae (Adenovirinae) • Genera: --- virus (Adenovirus) • Serotype: --- Nnumber or letter

  19. DNA VIRUSES • Poxvirus: (Pox : pock or pustule) • Herpesvirus: (Herpes : creeping) • Adenovirus: (Adeno : gland) • Hepadnavirus: (Hepa : liver, dna: DNA) • Papovavirus: (Pa: papilloma, Po: polyoma, Va: vacuolating agent) • Parvovirus: (Parvus: small)

  20. RNA VIRUSES • Orthomyxovirus, paramyxovirus (Myxo: mucus) • Rhabdovirus: (Rhabdos: rod) • Picornavirus: (Pico: small, rna: RNA) • Togavirus: (Toga: cloak) • Flavivirus: (Flavi: yellow)

  21. Reovirus: (R: respiratory, E: enteric, O: orphan) Arenavirus: (Arena: sand) Retrovirus: (Re: reverse, TR: transcriptase) Calicivirus: (Calix: cup) Coronavirus: (Corona: Crown)

  22. Morphology of Viruses

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