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MotifSpace --- one year review. Wei Wang Department of Computer Science University of North Carolina at Chapel Hill weiwang@cs.unc.edu. My Research. Data mining with bioinformatics applications MotifSpace: Graph-based Pattern Discovery in Protein Structures. Function.
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MotifSpace --- one year review Wei Wang Department of Computer Science University of North Carolina at Chapel Hill weiwang@cs.unc.edu
My Research • Data mining with bioinformatics applications • MotifSpace: Graph-based Pattern Discovery in Protein Structures Function Functional motifs carry out protein function 3D structure of a protein
G O C A T H S C O P MotifSpace Biological Experiments Protein Data Bank testable hypotheses Experimental validation protein structures protein family Pattern Filter Pattern Miner Protein Classifier Pattern Validation Subgraph mining Visualization Classification Feature selection structural patterns family-specific patterns Structural Pattern Database Functional Motifs Knowledgebase Indexing & Search Knowledge management Huan et al. ISMB’05 demo
What MSNFF Enables • Increased external visibility • Important for junior faculty • Broader collaborations • Seed funds to initiate new collaborations • Crucial for interdisciplinary collaborations which are often if high risks and high returns
As a Result … • Extending MotifSpace to study • RNA structures • Protein-protein and protein-ligand interactions • Chemical compounds • Broader collaborations • A systems biology approach to cardiovascular diseases • Complex trait analysis • In the future, • A center for bio-medical data mining
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