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Eric Niederhoffer, Ph.D. SIU-SOM

ERG Review. Eric Niederhoffer, Ph.D. SIU-SOM. How do FAs and glycerol from TGs contribute to gluconeogenesis? How is tissue-specific regulation of PFK1 differentially mediated in cardiac vs skeletal muscle vs hepatic tissue?

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Eric Niederhoffer, Ph.D. SIU-SOM

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  1. ERG Review Eric Niederhoffer, Ph.D. SIU-SOM

  2. How do FAs and glycerol from TGs contribute to gluconeogenesis? How is tissue-specific regulation of PFK1 differentially mediated in cardiac vs skeletal muscle vs hepatic tissue? How is PK activity modulated to favor gluconeogenesis and conversion of pyruvate to oxaloacetate? How is F6P production favored over F16BP formation during gluconeogenesis? Outline

  3. Fatty acids and glycerol contribute to gluconeogenesis TAG HSL Odd-chain FA oxidation/ AA metabolism Glycerol + FA PCoA MMCoAmutase TCA cycle L-MMCoA SCoA VitB12 Glc Glycerol G6P GlK F6P Gl3P F16BP Gl3PDH DHAP G3P

  4. F26BPase-PFK-2 Skeletal Muscle F6P↑ F6P↓ F26BPase-PFK-2 Ep Insulin F26BPase-PFK-2 PKA Heart ??? AKT/WISK F26BPaseP-PFK-2 Tissue-specific regulation of PFK-1 Glucagon Ep Insulin F26BPase-PFK-2P Liver PKA PrPase2A F26BPase-PFK-2

  5. Glucagon Glc G6Pase GK G6P F26BPase-PFK-2 Cortisol PKA F6P F26BPase-PFK-2P PFK-1 F16BPase F26BP F16BP CREB GR Protein PEPCK Ala OAA PEP PKA PK PKP MDH Mal Pyr PDHK PDHP PDH PC PDHP Acetyl-CoA ATP NADH OAA MDH Lipolysis β-Oxidation FA Mal TGA Ep, Glucagon, Cortisol HSL PK activity modulated to favor gluconeogenesis Cyt Mit

  6. Glucagon Glc G6Pase GK G6P F26BPase-PFK-2 Cortisol PKA F6P F26BPase-PFK-2P PFK-1 F16BPase F26BP F16BP CREB GR Protein PEPCK Ala OAA PEP PKA PK PKP MDH Mal Pyr PC OAA MDH Mal F6P production favored over F16BP during gluconeogenesis Cyt Mit

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