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Immunoglob ul ins.

Immunoglob ul ins. Immunoglob ul ins. -glob ul ins not globins. Immunoglob ul ins. -glob ul ins: any of a class of simple proteins that are insoluble in pure water but are soluble in dilute salt solutions…

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Immunoglob ul ins.

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  1. Immunoglobulins.

  2. Immunoglobulins. -globulins not globins

  3. Immunoglobulins. -globulins: any of a class of simple proteins that are insoluble in pure water but are soluble in dilute salt solutions… not globins: a colorless protein derived by removal of a heme from a conjugated protein

  4. ABSTRACT antibody

  5. Early history…

  6. The molecule:

  7. The molecule:

  8. Put proteins in space…

  9. Put immunoglobulins in space

  10. Put immunoglobulinsin two dimensions

  11. Put immunoglobulins in space

  12. Put immunoglobulins in space Ribbon model…

  13. Put immunoglobulins in space Space filling model…

  14. Put immunoglobulins in space Domain model…

  15. Amino acid composition of CDR’s

  16. Put immunoglobulins in space A bread and butter sandwich held together with a toothpick

  17. Wu-Kabat plot:

  18. Wu-Kabat plot: Examples: The lowest ratio: Wu-Kabat index = 1 = 1/1 The highest ratio: Wu-Kabat index = 400 = 20/0.05 A characteristic ratio for a CDR: Wu-Kabat index = 50 = 10/0.2 = 80 = 12/0.15

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