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The National Children’s Study

The National Children’s Study. Biospecimen Collections Mother – blood, urine, hair, nails , saliva, vaginal swab, breast milk Father – blood, urine, hair, nails , saliva Child – placenta (sections), cord blood, cord (section), meconium, blood, urine, hair, nails , saliva

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The National Children’s Study

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  1. The National Children’s Study Biospecimen Collections • Mother – blood, urine, hair, nails, saliva, vaginal swab, breast milk • Father – blood, urine, hair, nails, saliva • Child – placenta (sections), cord blood, cord (section), meconium, blood, urine, hair, nails, saliva • All biospecimens are aliquotted and stored • There is no ‘real-time’ analysis of biospecimens

  2. The National Children’s Study • Chemical Exposures classified by “Domain of Exposure,” sub-classified by “Specific Measure” • Allergens (pets, dust, mold) • Carbonyls (formaldehyde, acrolein) • Metals (Pb, Hg, Cd, Mn, Uranium, As) • Gaseous Air Pollutants (ozone, SO2) • Pesticides (carbamates, pyrethroids, atrazine) • VOCs (benzene, chloroform) • ETS • Nitrates • Halogenated Phenols, & more

  3. The National Children’s Study Chemical Exposure Measures divided into • Household & Community samples • Related Data Collection • Biological (blood, hair, nails, urine, breast milk) • Questionnaires • Observation (home, yard, neighborhood, agricultural area)

  4. The National Children’s Study How will Birth Defects be identified? • 1st Trimester U/S • Placenta photos, wt & dimensions, blocks &/or specimens • Dysmorphology Assessment Instrument exam after birth while still in hospital • PE at 6 & 12 months • NUMEROUS physical measurements of pregnant Mo & child throughout

  5. The National Children’s Study Data Collection related to Glucose Metabolism • HbA1C @ pre-pregnancy & 1st trimester • Glucose, insulin, IGF, & IGF-BP3 @ 3rd trimester

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