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Initial monotherapy and combination therapy and hypertension control the first year

Initial monotherapy and combination therapy and hypertension control the first year. Egan BM, Bandyopadhyay D, Shaftman SR, Wagner CS, Zhao Y, Yu-Isenberg KS. Hypertension . 2012;59:1124-1131 . Patient characteristics. 180 Clinical sites – 106 621 patients

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Initial monotherapy and combination therapy and hypertension control the first year

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  1. Initial monotherapy and combination therapy and hypertension control the first year Egan BM, Bandyopadhyay D, Shaftman SR, Wagner CS, Zhao Y, Yu-Isenberg KS. Hypertension. 2012;59:1124-1131.

  2. Patient characteristics • 180 Clinical sites – 106 621 patients • Patients included were untreated and uncontrolled for ≥6 months before initial therapy, and had ≥1 year of follow-up data Egan BM, Bandyopadhyay D, Shaftman SR, Wagner CS, Zhao Y, Yu-Isenberg KS. Hypertension. 2012;59:1124-1131.

  3. Main results • The majority of patients completed the year on their initial treatment category • Patients who ended on free combinations included both those on free combinations only and those on ≥2 free-dose medications with a single-pill combination • The single-pill combination group had higher: • Body mass index • Proportion of females • Proportion of patients with stage 2 hypertension • Proportion of patients with BP ≥20/10 mm Hg above goal Egan BM, Bandyopadhyay D, Shaftman SR, Wagner CS, Zhao Y, Yu-Isenberg KS. Hypertension. 2012;59:1124-1131.

  4. Single-pill combination better than free combination Single-pill combination Free combination Monotherapy 68% 59% 59% Control rate Days to control Egan BM, Bandyopadhyay D, Shaftman SR, Wagner CS, Zhao Y, Yu-Isenberg KS. Hypertension. 2012;59:1124-1131.

  5. Conclusion • Hypertensive patients begun on single-pill combinations were 53% more likely than those started on monotherapy to attain BP control in the first year. • Despite starting with higher untreated BP, patients who began treatment with single-pill combinations were more likely to achieve BP control than those started on free combination or monotherapy  Greater use of single-pill combinations as initial therapy improves hypertension control and cardiovascular outcomes in the first year of treatment. Egan BM, Bandyopadhyay D, Shaftman SR, Wagner CS, Zhao Y, Yu-Isenberg KS. Hypertension. 2012;59:1124-1131.

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