Topics For Today

1. Topics For Today • Connecting the amino acids…

2. Topics • Amines (review) • Amides (review) • Nylons (review) • Amino Acids • Proteins • Course Evaluations?

3. Readings for Today • 11.6 Proteins: First among equals • 11.7 Good nutrition and alternative diets: Getting enough protein

4. Topics for Wednesday • Natural Curls?

5. Topics for Wednesday • How do proteins get their shape? • Protein Video!

6. Chapter 12 • 12.3 Cracking the chemical code (p. 539 on proteins only)

7. Chapter 11 • 5.6 The role of hydrogen bonding

8. Announcements! HW 5 due this Thursday! Psst… easy 10 points!

9. Announcements! NOT here! Final Exam Friday, May 18 at 12:25 pm in 113 Psychology!

10. Announcements! Final Exam Don’t forget about the essay!

11. Topics For Today • Connecting the amino acids…

12. Review Where have we seen polyamides?

13. Manmade Nylon “Synthetic Silk”

17. Flexible and Robust! • Toothbrush bristles

18. Summary… Nylon 6,6 O H H O N C N (CH2)6 C (CH2)4 n Double Acid Double Amine Double Acid Double Amine AMIDE AMIDE AMIDE AMIDE AMIDE

19. Natural Polyamides

20. Proteins!

21. Where do we find proteins?

22. Blood Hemoglobin

23. Muscles Myoglobin

24. Skin Collagen

25. Wool Keratin!

26. Keratin! Fur and Hair

27. Keratin! Beaks Feathers Claws Fingernails

28. Proteins are polymers! Every polymer has a monomer….

29. Amino Acids! • The monomers of the protein polymer. And all of them look like… There are about 20 amino acids

30. Amino Acid THIS!!! H O H N C C H OH R

31. Amino Acid Functional Group? H O H N C C H OH R Amine!

32. Amino Acid Functional Group? H O H N C C H OH R Amine Acid

33. Amino Acid Then how do amino acids differ? H O H N C C H OH R Can be 1 of 20 (or so) different groups!

34. When R=H EXAMPLE H O H N C C H OH R

35. When R=H EXAMPLE H O H N C C H OH H Glycine (gly)

36. When R=CH3 EXAMPLE H O H N C C H OH R

37. When R=CH3 EXAMPLE H O H N C C H OH CH3 Alanine (ala)

38. The “R” can be about 20 different groups!

40. Amino Acids Can we categorize these? Glycine (gly) Alanine (Ala) Valine (Val) Leucine (Leu) Isoleucine (Ile) Proline (Pro) Tryptophan (Trp) Phenylalanine (Phe) Serine (Ser) Threonine (Thr) Tyrosine (Tyr) Aspartic acid (Asp) Glutamic acid (Glu) Asparagine (Asn) Glutamine (Gln) Lysine (Lys) Arginine (Arg) Histidine(His) Cysteine (Cys) Methionine (Met)

41. 1st Category of Amino Acids a) nonpolar, neutral b) polar, neutral c) acidic d) basic

42. 1st Category of Amino Acids a) nonpolar, neutral b) polar, neutral c) acidic d) basic

43. Nonpolar, neutral • The R group is a hydrogen or a hydrocarbon H O H N C C H OH R

44. When R=CH3 EXAMPLE H O H N C C H OH CH3 Alanine (ala)

45. When R=H EXAMPLE H O H N C C H OH H Glycine (gly)

46. Leucine EXAMPLE

47. Isoleucine EXAMPLE

48. Nonpolar, neutral • The R group is a hydrogen or a hydrocarbon The side chain (R group) is hydrophobic (water hating)!

49. 1st Category of Amino Acids a) nonpolar, neutral b) polar, neutral c) acidic d) basic

50. Polar, neutral • When the R group contains sulfur, an alcohol, or is an amide