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Genomics and You

Discover the power of genomics in public health and understand why it is relevant to you. Learn about the differences between genetics and genomics, debunk misconceptions, and explore the potential interventions and applications in improving public health outcomes. Overcome challenges and explore ethical, legal, and social issues. Join the genomic revolution in public health!

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Genomics and You

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Presentation Transcript

  1. Genomics and You “What is it and why now?”

  2. Overview • Genetics vs. Genomics • Misperceptions • Applicability to public health • Challenges

  3. Genetics vs. Genomics • Genetics: study of single genes and their effects (cystic fibrosis) • Genome:all the genetic material (DNA) of an organism

  4. Genetics vs. Genomics • Genomics:study of all the genes in the genome, including their interactions with environmental factors (heart disease, asthma)

  5. Misperceptions • “Genomics isn’t relevant to me or the area of public health in which I work” • Did you know that … 9 of the top 10 causes of death in the U.S. have a genetic component?

  6. Top 10 Causes of Death in the U.S. (2000) • Heart Disease • Cancer • Cerebrovascular Disease • Chronic Lower Respiratory Disease • Accidents/Unintentional Injuries • Diabetes • Pneumonia/Influenza • Alzheimer’s Disease • Kidney Disease • Septicemia

  7. Misperceptions • “Genetic susceptibility equals health destiny” • Diseases can be caused solely by genetics. However, most diseases are caused by gene-environment interactions

  8. Genetic Susceptibility is NOT Health Destiny Genetics is just one piece of the “puzzle”

  9. Misperceptions • “There are no interventions based on genomics” It’s true, we can’t change our genes. BUT we can use this knowledge to …

  10. Potential Interventions • Modify screening and medical recommendations • More Frequent Screenings • Genetic Testing/Evaluation • Interventions or Prevention

  11. Potential Interventions • Modify exposure to environmental factors that may interact with known genetic susceptibilities • Pesticide Exposure • Genetic Screening for agricultural workers at high-risk

  12. Potential Interventions • Target messages and interventions aimed at changing behaviors of high-risk groups • Diet • Physical Activity • Smoking Cessation • Alcohol Avoidance • Others?

  13. Genomics and You • What are some examples of public health genomics? • Did any of these activities apply to you?

  14. Family History • Powerful tool that can identify genetic, behavioral, social, environmental, and cultural factors

  15. Should We Wait? • Direct-to-consumer marketing of BRCA genetic test • Genetic profiles for nutrition, drug response, osteoporosis, and heart disease • Genetic tests available for over 900 conditions

  16. Overcoming Challenges • Potential discrimination in health insurance or employment • Access to genetic services for all populations Ethical, Legal, and Social Issues (ELSI)

  17. Overcoming Challenges Genomics won’t change the goals of public health. But it can be used as a tool to help target at-risk populations, through tailored messages and interventions.

  18. Genomics and You “Genomics will be to the 21st century what infectious disease was to the 20th century … Genomics should be considered in every facet of public health: infectious disease, chronic disease, occupational health, environmental health, in addition to maternal and child health” - “Gerard et al. Journal Law, Medicine, Ethics 2002; vol 30 (suppl): 173-176”

  19. Thank You! • Questions or comments? • Contact Us • Chronic Disease Genomics Program • Rebecca Giles rgiles@utah.gov • Jenny Johnson jennyjohnson@utah.gov • Jess Agraz jagraz@utah.gov

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