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Effectiveness of Rituximab treatment in primary Sjögren’s syndrome

Effectiveness of Rituximab treatment in primary Sjögren’s syndrome A randomized, double-blind, placebo-controlled trial JM Meijer, et al. Arthritis Rheum 2010. Rituximab, AC monoclonal anti-CD20 (LMNH, PR, lupus…) SSP, BGSA+, FR et anti-SSA/SSB, majeur, débit salivaire  0,15 ml/min

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Effectiveness of Rituximab treatment in primary Sjögren’s syndrome

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  1. Effectiveness of Rituximab treatment in primary Sjögren’s syndrome A randomized, double-blind, placebo-controlled trial JM Meijer, et al. Arthritis Rheum 2010 • Rituximab, AC monoclonal anti-CD20 (LMNH, PR, lupus…) • SSP, BGSA+, FR et anti-SSA/SSB, majeur, débit salivaire  0,15 ml/min • Rituximab 1000 mg J1J15 (n=20) vs placebo (n=10) Effet sur débit salivaire, fatique, scores de sd sec, signes extra-gland. Bonne tolérance (1 cas de maladie sérique) Dans le SSP, le Rituximab améliore le débit salivaire chez les patients ayant un débit résiduel, avec un bon ratio bénéfice/risque

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