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Osteoscoop - Issue N°148 - September 2010

Strontium Ranelate vs. Alendronate on Bone Microarchitecture as Assessed by HR- pQCT in Postmenopausal Women. Osteoscoop - Issue N°148 - September 2010. Strontium ranelate 2 g/jour. N = 88. Alendronate 70 mg/semaine.

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Osteoscoop - Issue N°148 - September 2010

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  1. Strontium Ranelate vs. Alendronate on Bone Microarchitecture as Assessed by HR-pQCT in Postmenopausal Women Osteoscoop - Issue N°148 - September 2010

  2. Strontium ranelate 2 g/jour N = 88 Alendronate 70 mg/semaine M0 M3 M6 M12 M18 M24 Selection Inclusion Preplanned interim analysis

  3. Bone Micro-structure« Virtual Biopsy » Distal Radius • 82 µm resolution (HR-pQCT) • 2.6 min acquisition time • < 5µSv radiation dose Distal Tibia

  4. Benefits of strontium ranelateon bone are significant after 3 months Cortical thickness Relative change from baseline (%) 6.0 * 5.0 Strontium ranelate 4.0 * 3.0 2.0 1.0 Alendronate Alendronate 0.0 months months 3 0 6 12 *P<0.05 vs alendronate Rizzoli R, et al. Rheumatol Int. 2010 (accepted).

  5. Benefits of strontium ranelateon bone are significant after 3 months Cortical thickness Bone Volume/Tissue Volume Relative change Relative change from baseline (%) from baseline (%) 6.0 2.5 * * 2.0 5.0 Strontium ranelate Strontium ranelate 1.5 4.0 1.0 * 3.0 0.5 * Alendronate 2.0 0.0 1.0 - 0.5 Alendronate Alendronate 0.0 - 1.0 months months months months 3 3 0 6 12 0 6 12 *P<0.05 vs alendronate Rizzoli R, et al. Rheumatol Int. 2010 (accepted).

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