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PCOS and Hyperinsulinemia

Metabolic Syndrome. Constellation of metabolic abnormalities Excess weightHigh blood pressureDyslipidemiaHyperglycemiaAlso considered:Insulin resistanceInflammationThrombosisHyperuricemiaRenal function. NCEP/ATP III Criteria -Metabolic Syndrome. (1) Abdominal obesityMen: wai

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PCOS and Hyperinsulinemia

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    1. PCOS and Hyperinsulinemia

    2. Metabolic Syndrome Constellation of metabolic abnormalities Excess weight High blood pressure Dyslipidemia Hyperglycemia Also considered: Insulin resistance Inflammation Thrombosis Hyperuricemia Renal function

    3. NCEP/ATP III Criteria -Metabolic Syndrome (1) Abdominal obesity Men: waist circumference > 40 inches Women: waist circumference > 35 inches (2) Fasting glucose = 110 < 126 mg/dL (3) Blood pressure = 130/85 mm Hg (4) Triglycerides = 150 mg/dL (5) HDL-C Men < 40 mg/dL Women < 50 mg/dL Syndrome is present when three or more criteria are met. G. Reaven, Endocrinol Metab Clin N. Am 33 (2004) 283-303

    4. Obesity Augmenting Risk Products of adipose tissue include: Non-esterified fatty acids (NEFA); influx of NEFA into liver resulting in increase influx of apB-containing lipoproteins into circulation Inflammatory cytokines PAI-1

    5. Prevalence Metabolic Syndrome National Health and Nutrition Examination Survey III (NHANES III); 1988-1994 Men Women 24.8% whites 22.8% 25.7% African Americans 25.7% 35.6% Mexican Americans 35.6% 19.9% Other 19/9%

    6. Insulin Resistance and Hyperinsulinemia Associated with PCO Worsens with obesity Increased Triglycerides Atherogenic lipid profile Cardiovascular disease

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