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IPHY 3430 10-04-11

IPHY 3430 10-04-11. Circulatory System Purposes: Delivery of O2, energy containing substrates, vitamins and other nutrients to cells; Removal of CO2, secretory products, and waste products from cells.

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IPHY 3430 10-04-11

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  1. IPHY 3430 10-04-11

  2. Circulatory SystemPurposes:Delivery of O2, energy containing substrates, vitamins and other nutrients to cells;Removal of CO2, secretory products, and waste products from cells.

  3. Topicsa. blood constituentsb. transport of gasesc. heart functiond. blood pressuree. blood volume and lymphatic system

  4. Additional components of the circulatory system:Medulla vasomotor centerSNS, PNSAnd, blood...

  5. Components of Blood:Cells: red blood cells, white blood cells, and plateletsPlasma: water proteins a. Albumin b. globulins (,,) c. Fibrinogen ions glucose, amino acids wastes (creatinine, urea, ammonia)

  6. Transport of Oxygen3% transported dissolved in plasma97% transported in red blood cell in association with hemoglobin

  7. Red blood cellsMen: 5 million/ml bloodWomen: 4.5 million/ml blood25-30 trillion rbc’s in total blood volume120 day life spanno nucleus, mitochondria nor ribosomes4 heme groups (Fe plus pyrroles) + 4 globin molecules

  8. Hemoglobin bindingon heme groups1. O2 2. CO on globin chains3. CO24. H+5. Nitric oxide (NO)6. 2,3 biphosphoglycerate

  9. Regulation of red blood cell production RBCs (O2 delivery) ---> Kidney (both sensor and integrator)--->  secretion of erythropoietin -->  stimulation of bone marrow to produce RBCs --> RBCs (O2 delivery)  RBCs (O2 delivery) ---> Kidney (both sensor and integrator)--->  secretion of erythropoietin --> stimulation of bone marrow to produce RBCs --> RBCs (O2 delivery)

  10. Pathological variation in RBCsAnemias (30% and below)1. Iron deficiency2. Lack of folic acid in diet3. Pernicious4. Hemorrhagic5. Aplastic6. Hemolytic7. Renal

  11. Regulation of red blood cell production RBCs (blood PO2) ---> Kidney (both sensor and integrator)--->  secretion of erythropoietin -->  stimulation of bone marrow to produce RBCs --> RBCs (PO2)   RBCs (blood PO2) ---> Kidney (both sensor and integrator)--->  secretion of erythropoietin --> stimulation of bone marrow to produce RBCs --> RBCs (PO2)

  12. Pathological variation in RBCsPolycythemia (70% and above)1. Polycythemia vera2. Chronic high altitude mountain sickness

  13. Relation between hematocrit and oxygen transport Normal hematocrit Blood doping O2 transport Hematocrit

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