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Wild Type Drosophila. Ommatidium. 8 Photoreceptor cells (R1-R8) 4 Cone cells (secrete lens) 8 Pigment cells. Wild Type Eye Phenotype. Eyeless Mutant Phenotype (hypomorphic allele). Paired Domain Protein. DNA. Figure 1A. Gal4 Enhancer-Trap Method. LacZ. No Transcription of LacZ.
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Ommatidium 8 Photoreceptor cells (R1-R8) 4 Cone cells (secrete lens) 8 Pigment cells
Eyeless Mutant Phenotype (hypomorphic allele)
Figure 1A Gal4 Enhancer-Trap Method LacZ No Transcription of LacZ
Figure 1A Gal4 Enhancer-Trap Method LacZ Enhancer that controls expression in specific tissues
Figure 1A Gal4 Enhancer-Trap Method LacZ Tissue-specific Expression of Gal4 Tissue-specific Expression of LacZ
Figure 1 Eye-Antennal disc wing disc leg disc
Figure 1A Gal4 Enhancer-Trap Method LacZ Enhancer that controls expression in imaginal disc cells Transcription of LacZ in imginal disc cells
Figure 1A Enhancer that controls expression in imaginal disc cells Transcription of eyeless in imginal disc cells
Paired Domain Protein DNA Drosophila ey, mouse Pax-6 (sey) and Human Pax-6 (Aniridia) genes are ~ 94% similar in Paired domain
Ectopic Expression of Mouse Pax-6 Gene Pax-6 Enhancer that controls expression in imaginal disc cells Transcription of Pax-6 in imginal disc cells
Figure 5 Ectopic Expression of Mouse Pax-6 Gene
Aniridia -- Human Pax-6 Mutation Absence of the iris
Xenopus Oocyte Animal Pole Vegetal Pole
Xwnt-11 mRNA Localization Xwnt-11 is Drosophila wingless homogue
Ventralized Normal
Goosecoid Protein Expression
Embryo Grafting Experiment Inject mRNAs For Chordin etc.
Normal Dorsalized