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The AER is required for limb differentiation.

The AER is required for limb differentiation. Progressive Effects of Removal of the AER During Limb Development. Limb Polarity and Axes. Gene Inductions: (dorsal) Paraxial Mesoderm K Radical Fringe+ Wnt-7a+ K Lmx-1+ (ventral) Lateral Mesoderm K Engrailed-1 ,, (Limits) Wnt-7a+.

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The AER is required for limb differentiation.

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  1. The AER is required for limb differentiation.

  2. Progressive Effects of Removal of the AER During Limb Development

  3. Limb Polarity and Axes

  4. Gene Inductions: (dorsal) Paraxial Mesoderm K Radical Fringe+ Wnt-7a+ K Lmx-1+ (ventral) Lateral Mesoderm K Engrailed-1 ,, (Limits) Wnt-7a+ Origins of Limb Primordia:

  5. Local effects of FGF on expression of some Hox genes involved in limb development

  6. Zone of Polarizing Activity Localized in the posterior margin of limb bud Specifies polarity of limb field Specifies existence of limb field

  7. ZPA May be (or) induce activity of Sonic hedgehog genes And Hox D genes

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