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Some TNF a induced signaling pathways

Some TNF a induced signaling pathways. TNF-mediated clustering. TNF a. TNF a. TNFR1. TNFR2. TNF-Receptor 1. TNF-Receptor 2. (p55). (p75). TRAF2. DD. FADD. TRADD. TRAF-domain. TRAF2. TRAF1. IAP1/2. Death domain. Pro-Caspase-8. NIK. NIK. IKK g. RIP. Caspase-8. P. GCK.

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Some TNF a induced signaling pathways

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  1. Some TNFa induced signaling pathways TNF-mediated clustering TNFa TNFa TNFR1 TNFR2 TNF-Receptor 1 TNF-Receptor 2 (p55) (p75) TRAF2 DD FADD TRADD TRAF-domain TRAF2 TRAF1 IAP1/2 Deathdomain Pro-Caspase-8 NIK NIK IKKg RIP Caspase-8 P GCK IKAP MAPKKKs IKK1 IKK2 P IkB Phosphorylation on Tyr42 (via c-Src) Apoptosis MEKK1 IkB degradation in proteasomes MKK6 IkB phosphorylation (S32,36) ubiquitinylation MKK7 JNK pathway p38 pathway p65 phosphorylation on S276 PKA pathway LPS NFkB p50 p65 p38s SAPKs (JNKs) p65 phosphorylation on Ser529 p38 pathway Jun, Elk, Fos, ATF2 CBP.. co-activators AP-1 mRNA for inflammatory genes, IkB, IAPs, A20, TRAFs,... P transcription DNA Johannes Schmid 12/98 nucleus

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