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Exon 1 UBA*0301 ----------MKCFILLLLGIA-LHSSSA UBA*1001 ----------PL..........-......

Exon 1 UBA*0301 ----------MKCFILLLLGIA-LHSSSA UBA*1001 ----------PL..........-...... ULA*0102 ----------.........S.S-..AA.. UGA*0101 ----MKTRLISAMK.YFV.LSC-I.GALS UDA*0101 ----------..G...MFM.TCH.FEAFG UHA1*0101 --------------MV.W.CLS-.RTANS

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Exon 1 UBA*0301 ----------MKCFILLLLGIA-LHSSSA UBA*1001 ----------PL..........-......

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  1. Exon 1 UBA*0301 ----------MKCFILLLLGIA-LHSSSA UBA*1001 ----------PL..........-...... ULA*0102 ----------.........S.S-..AA.. UGA*0101 ----MKTRLISAMK.YFV.LSC-I.GALS UDA*0101 ----------..G...MFM.TCH.FEAFG UHA1*0101 --------------MV.W.CLS-.RTANS UHA1*0201 --------------MV.W.CLS-.RTANS UHA2*0101 ---------MGGQILV.W.CLS-.RTANS ZAA*0201 ------MNISHLTVFV.YFSLECICQ.GK ZBA*0101 --------MYTFMLFVFYFSTECIVQ.QS ZCA*0101 --------MYTFMLFVFYFSTECIVQ.QS LBA MRGYTIKIMGKLSVF.FVFSFYTIV.PGS SAA*0101 --------------MITTIL.SFMQF.IV HLA-A2 -----MAVMAPRTLV...S.ALA.TQTW. -20 -10 Exon 2 # # # !!!!! UBA*0301 ATHSLRYVYTATSGIPDFP---EFVTVGLVNGEPISYYD--SIIRRETPRQDWMAKTEGSDYWESQTQVSIGSEQTFKANIDVAKQRFN-QTG UBA*1001 VI..WKAFL..ST.LS...---...ALN..DD.LMG.F.--TKTN.FEGK.S.VEEKL.QQ.L.Q.ENILRSTS.S..V.VGI.ME...-..K ULA*0102 .M............M....---..M..............--.............KEAVDP...NRN..T...D................-... UGA*0101 VI.....F..SS...S...---...DM.M..DQV..H..--..TK.KV.K.S..G.VFDQQ..D.T.EDLR.A.KV..N.LQT.QK...-... UDA*0101 V....KHF...S.KVTN..---..MV..M.D.VQ.DH..--.N.Q.MV.K....N.QTEAE...RE.GIAFD.Q.V..DDVNIL.....-.S. UHA1*0101 .N...K.F...LPQSTGL.---..SA.AYLDE..MYF..--.STKEVVA..E.VKGAVDP.F.RRN..ILKEN.MV..D.M.T.RD...-.. UHA1*0201 .N...K.F...LPQSTGL.---..SA.AYLDE..MYF..--.STKEVVA..E.VKGAVDP.F.RRN..ILKEN.MV..D.M.T.RD...-.. UHA2*0101 .....K.F...LPQSTGL.---..SA.AYLDE..MYF..--.STKEVVA..E.VKEAVDP.F.RRN.HIFKET.KV..Y.M.S.RD...-.. ZAA*0201 D.Y..S.I...L.KPV.L.GIH..TAM..M.NQQ.D...--.VSKKKI.K....REKLPA....KG..SRKSK..W..V.V.ILMK.MRHNNT ZBA*0101 EIY..N.I...L.KPVEL.GIH..TAM..M.DIQ.D...--.VDKKKI.K....REKLPA....KG..SRKRK..W..V.VNILME.MRHNNT ZCA*0101 EIY..N.I...L.KPVEL.GIH..TAM..M.NRQ.D...--.VDKKKI.K....RDKLPA....KG..SRKSK..W..V.VNILME.MRHNNT LBA GS...WALA.YIV.ETP..---..TV.VMLDDVQVA...--.NDKQSVY.GQHIT..KDDEAQDG-AH.FRVIY.SM.DRSFEL.H...-L.E SAA*0101 .P...HRHCI..Q.-TLY.---KNIQLVMIDDVTVY..N--.SAEQ.AVVPE.LNHL..IEF.QEVNRNLKF.RFVMDTAVR.TSEHY.--HS HLA-A2 GS..M..FF.SV.RPGRGE--PR.IA..Y.DDTQFVRF.SDAASQ.ME..AP.IEQEGPE-..DGE.RKVKAHS..HRVDLGTLRGYY.QSEA * 20 * 40 * 60 * 80 * Exon 3 # # ## # # UBA*0301 GVHVNQKMYGCEWDDETG----VTEGFDQDGYDGEDFLAFDLKTLTWIAPTPQAVITKLKWDSNTAQNEYRKNYLTQTCIEWLKKYLDYG-KSTLMRT UBA*1001 ....F.N...........----.................................N..H.......Y..QE......I........V...-....... ULA*0102 ....Y.N.........A.----.......Y...............K.......SL.......N.M..IQQD.H.................-....... UGA*0101 .M.IS.D...........----L....HHI....Q.L.V....RA....SV...LHS.M..EGDPSSI.SE.R....D..V......E..-.T..Q.. UDA*0101 ....L.YI...S.....E----QRD..G.L..N.....VY.MN....K.LKQ..DVMRD..NRDISRLVFW.T.FS.....C...QVVN.-....RT UHA1*0101 SAL.L....S.D..EV..----A.DERE.Y..G.....L....NKR..V.GR.GL...M...A.VIKL.AKIH...H.........VSNW-RRN.E.. UHA1*0201 SAL.L....S.D..EV..----A.DERE.Y..G.....L....NKR....GR.GL...M...A.VIKL.AKIH...H.........VSNW-RRN.E.. UHA2*0101 SALAL....S.D...V..A---A.D.RE.Y..G.....S....NER....GR.GL...M...A.VIKLKAKIH...H.........VSNR-RRN.Q.. ZAA*0201 D...L.WKV...I.QQSDGTLKFIK.I..YS...D......DV.MQ.V..VD..LP..R.L.DVQIL.T.T.G..EKE.VD..S.FME.ED.EFSWAD ZBA*0101 D...L.WRH...V.KQPDGTLKFMK.I..YS...D......DV.MQ.V..VD..LP..R...GVQIL.Q.T.G..EKE.VD..S.FME..E.HFSSTD ZCA*0101 ..RIL.WKH...V.KQPDGTLKFIK.T..YS...D......DV.MQ.V..VD..LP..R...GVQIL.Q.T.G..EKE.VD..S.FME..E.HFSSAD LBA ..Q.Q..IT...MLNNGESALVMYKDVFNAI.TDR-T.YYNMTHF.YD.G--KLLLGWDGIRQAYERTL.ENV..P-I..KS..RL.KRE-.NIV..K SAA*0101 HD.FY.AHGR.G.KSDGT-----..A.MSHA...K..VS..VS.R..T.AVSH..FY.R.RETDLEDLVRLVIHYESG..R....L.QFS--V.FREP HLA-A2 .S.TV.R....DVGSDWR----FLR.YH.YA...K.YI.LKEDLRS.T.ADMA.QT..H..EAAHVAEQL.-A..EG..V...RR..EN.-.E..Q.. 100 * 120 * 140 * 160 * 180 Exon 4 b b b  UBA*0301 VPPSVSLLQKTPSSP----VTCHATGFYPSGVMVSWQ-KDGQDHHED--VEHGETLQNDDGTFQKSSHLTVTPEEWKNNK-YQCVVQVTGLQEDFIKVLTESEIKTNW UBA*1001 ...............----..................-.........--..Y............................-........................... ULA*0102 ...............----..................-.........--..Y............................-.........VK................GNTNI UGA*0101 ...............----...............F..-.........--..N....H........RT..K..S.......-.........IK............Q..R UDA*0101 A..............----...............F..-....EQ...--.....I.H.........T..R..........-.........IK............Q... UHA1*0101 ...Q......E..N.----..........NAI.IF.G-R..VEI.A.--.V.E...P.G...Y..RI....S..DLQQHN-.T.T..HVR-GD.VVLSANRDS.RS.SRNTQ UHA1*0201 ...Q......E..N.----..........NAI.IF.G-R..VEI.D.--.V.E...P.G...Y..RI....S..DLQQHN-.T.T..HVR-GD.VVLSANRDS.RS.SRNTQ UHA2*0101 ...Q......E..N.----..........NAI.IL.G-R..VEI.D.--.V.E...P.G...Y..RI....S..DLQQHN-.T.T..HIR-GD.VVLSANRDS.RS.SRNTQ ZAA*0201 SA.K.YAFA.KAKTAGHVRL..M......KD.VMHIK-.N.VPLTDRDG.QSAGL.P...E.Y.IRMSVQIP--.ADKET-.E.Y.NHRA.K.PIVVKW ZBA*0101 S..NIYVFT.KAKPAGNVHL..MV.....KD.IIHFK-.N.VQLT..DG.LSTGARP.N.D.Y.IRISVQIP--.ADKDM-.E.S.SHAM.K.PIVEKW ZCA*0101 S..DINVFANKAKTAGNVHL..M......KD.IIHFK-.N.VQLT..DG.LSTGARP.N.D.Y.IRISVQIP--.ADKQT-.E.S.SHIT.VQPIVVKWGKVVLVF.ILYIFSTN LBA ...RLR.IK.EV.GG--FQ.S.L.F....RHINLTLL-R...PVA.Q-ELTG..V.PSG...Y.LRKS.E.ST..L.KRHN.T.TASHLS.DNKLDVSWESG--AERVHL SAA*0101 KV.A...FERP.HGNSEVE....V.....RA.Q.E.LGAE.LPMVDG--.SS..V.P.G..SY.LRKS...PQ.AQDTQS-.S.L.LHSSIAGNITVTW HLA-A2 DA.KTHMTHHAV.DHEAT-LR.W.LS...AEITLT..-R..E.QTQ.--T.LV..RPAG......WAAVV.P--SGQEQR-.T.H..HE..PKPLTLRWEP.SQP.IPIV * 200 * 220 * 240 * 260 * 280 Exon 5-7 UBA*0301 ----NDPN--IVLIIGVVVALLLVVVA--VVVGVVIWK------KKSKKGFVPASTSDTDSDNSGRAAQMT UBA*1001 ----....--.....V.......L...--.........------........................L.. ULA*0102 -------------------------------------------------.....N...VG.NS.HNTVPKE UGA*0101 ----GVNTIGSAP.........V...V---...L.M.RR-----.................E...KG..KI UDA*0101 ----G..API..P...G.........V----.......------............N....VY..KDLLK. UHA1*0101 ------GISI.IYMVL.L.IIVI.IKRKAWKRK.SLL.KSVHLLINA.TAEMEKPKKRHSA.TLQIQLVP.ERPTEAEQFPQASTVC UHA1*0201 ----------EMENQKSEYCQGSPSSS----TWSWY.S----------SSSL UHA2*0101 ------GHYITIVLVTLAFSVIV.FIM------TKVC.-----------.KE.TAGKEKQCPSEY ZAA*0201 DGKCC.CSSGGAVV..A..IAFI..LI---L..LFVLH---------RR.TIGR. ZBA*0101 ----GAG.TGAPPPT.--IQAS.IGNG---------------------N.ATNLNLTT.P.KTLFQYL ZCA*0101 ------QLFAWLS.MVKSISKMF.CYK--------VTN-----------ADLNVNQQLFQAHCI.FCC SAA*0101 ----APKKNLANVLMAI.IIVSV.LIL---T.LFKYLV---------RRRA.A LBA -------STLS..LMMLLILI..GIFI----CVKRR.S------NTASQSELANVDAKVSEEMNLSSDSE. HLAA2 ------GIIAGLVLF.A.ITGAV.AAV------MWRR.S-----SDR.G.SYSQAA.SDSAQG.DVSLTACKV * 300 * 320 * 340

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