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Lecture 4

Lecture 4. Glycogen Synthesis Pentose phosphate pathway. Synthesis of Glycogen and Starch. Add glucose to non-reducing end Create (14) link Create (16) branches Glycogen Amylopectin Activate precursor with good leaving group Not a simple reversal of catabolism.

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Lecture 4

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  1. Lecture 4 Glycogen Synthesis Pentose phosphate pathway

  2. Synthesis of Glycogen and Starch • Add glucose to non-reducing end • Create (14) link • Create (16) branches • Glycogen • Amylopectin • Activate precursor with good leaving group • Not a simple reversal of catabolism

  3. Glycogen Phosphorylase in Liver

  4. Activated Precursor: UDP-Glc

  5. Glycogen Particles • Mr 106 Da Branches • 1 per 10 Glc • Bound enzymes • Glycogenin • Glycogen synthase • Glycogen phophorylase • Phosphorylase kinase

  6. Synthesis of Glycogen

  7. Synthesis of Glycogen

  8. Synthesis of Glycogen

  9. Synthesis of Glycogen

  10. Synthesis of Glycogen

  11. Synthesis of Glycogen

  12. Elongation of Glycogen Chain

  13. Branch Production • Moves 6-7 residues (4 shown due to space constraints) • Creates new non-reducing ends

  14. Pentose phosphate pathway

  15. Pentose phosphate pathway

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