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Mad Cow Disease-----. -- The Past History of Mad Cow Disease -- All about Mechanisms -- Other analogous diseases -- Great impact Mad Cow Disease Had Caused B9202066 湛茗任 B9202097 藍士耘 B9202099 魏士傑 B9202101 龔瑋翔. The Past History Of Mad Cow Disease. Early history in 1913
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Mad Cow Disease----- -- The Past History of Mad Cow Disease -- All about Mechanisms -- Other analogous diseases -- Great impact Mad Cow Disease Had Caused B9202066 湛茗任 B9202097 藍士耘 B9202099 魏士傑 B9202101 龔瑋翔
The Past History Of Mad Cow Disease • Early history in 1913 • 1957 Carleton Gajdusek in New Guinea • 1976 Nobel Prize in Medicine • 1982 Stanley B. Prusiner’s experiment • 1997 Nobel Prize in Medicine
Before introducing the early history of Mad Cow Disease, we sincerely hope all of you know …… Mad cow diseaseCow = Creutzfeldt-Jakob disease&KuruMen = ScrapieSheep
Early History in 1913 1. The story of Dr.Creutzfeldt 2. The story of Dr.Jakob
1957 Carleton Gajdusek in New Guinea About “Kuru” ………….
What Causes Mad Cow Disease • In 1982,Stanley B. Prusiner purified the pathogen of mad cow disease in his laboratory. • He found that the pathogen was composed of a kind of protein and named it proteinaceous infectious particle.
Actually, there are two kinds of prion, PrPc and PrPsc • PrPc can be found in the brain of normal, health animals and does not cause diseases. • PrPsc is the prion that causes diseases.
The polypeptides that form PrPc and PrPsc are the same, but PrPsc is misfolded. The main secondary structure of PrPc is α-helix while that of PrPsc is β pleated sheet. • PrPsc can convert the PrPc it meets to the malady-caused structure.
PrPsc can be metabolic and will be stored in the neuron of the brain then kill the cell. • If too many neurons are exterminated, the brain will lose it’s original function and the symptons of the disease appears.
How Do Mad Cow Disease Spread? • In order to made cows grow better, people mixed the powder of bones they got after slaughtering with feed. • While making sheep bone powder, the prion that caused scrapie was mixed with it and then eaten by cows. • Prion won’t be decomposed in the stomach and intestine, and will be absorbed and transported into the brain.
Diseases related to the Prion (TSEs)Transmissible Spongiform Encephalopathies Kuru CJD (Creutzfeld-Jacob Disease) Scrapie
Diseases related to the Prion (TSEs) • GSS (Gerstmann - straussler syndrom ) 遺傳性PrP基因突變 • CWD (Chronic wasting disease ) 狂鹿症 • FFI (Fatal familial Insomnia) 致命家族失眠症
Chain Reaction Wheat Cattle Corn Beans Beef Fast Food Cream
Influence • Stock Market • Exchange Rate • Livestock Breeding • Biotechnology and Medicine Industry
Epidemic • Quarantine • Kill All!!! • Globalization?