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Immune system itself Neuro-endocrine system

Components of Immune Regulation. Immune system itself Neuro-endocrine system. Effects of Immune Regulation. Positive events: Enhancement of immune response. Negative events: Suppression of immune response. Positive events: Enhancement of immune response. Target cells. Th1. CKs.

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Immune system itself Neuro-endocrine system

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  1. Components of Immune Regulation • Immune system itself • Neuro-endocrine system DEPARTMENT OF IMMUNOLOGY

  2. Effects of Immune Regulation • Positive events: Enhancement of immune response. • Negative events: Suppression of immune response. DEPARTMENT OF IMMUNOLOGY

  3. Positive events: Enhancement of immune response. Target cells Th1 CKs Tc MHC CK NK APCs Ag MHC CK Th2 CKs B Ab PMN Complement DEPARTMENT OF IMMUNOLOGY

  4. Negative events: Suppression ofimmune response. Target cells Th1 CKs Tc MHC CK NK APC Ts Ag MHC CK Th2 CKs B Ab PMN Complement DEPARTMENT OF IMMUNOLOGY

  5. Immune Response(IR) Target cells Th1 CKs Tc MHC CK NK APCs Ag MHC CK Th2 CKs B Ab PMN Complement DEPARTMENT OF IMMUNOLOGY

  6. Ag concentration DEPARTMENT OF IMMUNOLOGY

  7. Antigen Presentation Target cells Th1 CKs Tc MHC CK NK APC Ag MHC CK Th2 CKs B Ab PMN Complement DEPARTMENT OF IMMUNOLOGY

  8. MHC-Ag peptide complex formation ?? DEPARTMENT OF IMMUNOLOGY

  9. Immune Response(IR) Target cells Th1 CKs Tc MHC CK NK APC Ag MHC CK Th2 CKs B Ab PMN Complement DEPARTMENT OF IMMUNOLOGY

  10. Th1 and Th2 balance IFNr Th1 Th2 IL-4/10 + + APC DEPARTMENT OF IMMUNOLOGY

  11. DEPARTMENT OF IMMUNOLOGY

  12. Immune Response(IR) Target cells Th1 CKs Tc MHC CK NK APC Ts Ag MHC CK Th2 CKs B Ab PMN Complement DEPARTMENT OF IMMUNOLOGY

  13. -- CD4+CD25+ Regulatory T cells Self-reactive T cell CD4+CD25+ Treg cells DEPARTMENT OF IMMUNOLOGY

  14. DEPARTMENT OF IMMUNOLOGY

  15. Functions of CD4+CD25+ Treg cells Suppressive function : • Produce cytokines: IL-10/TGFβ • T-T interaction Treg CD4+CD25+ T CD4+CD25- APC DEPARTMENT OF IMMUNOLOGY

  16. Functions of CD4+CD25+ Treg cells Suppressive function : • Produce cytokines: IL-10/TGFβ • Cell-cell contact DEPARTMENT OF IMMUNOLOGY

  17. Immune Response(IR) Target cells Th1 CKs Tc MHC CK NK APC Ts Ag MHC CK Th2 CKs B Ab PMN Complement DEPARTMENT OF IMMUNOLOGY

  18. Antibody Production by B cell Th2 DEPARTMENT OF IMMUNOLOGY

  19. Antibody response (Humoral immune response) Ag + Ab DEPARTMENT OF IMMUNOLOGY

  20. Ag + Ab mediated B cell 图12-1抗原-抗体（IgG）复合物交联BCR和FcgRⅡ-B对B细胞抑制作用示意图 B cell DEPARTMENT OF IMMUNOLOGY

  21. Immune Response(IR) Target cells Th1 CKs Tc MHC CK NK APC Ts Ag MHC CK Th2 CKs B Ab PMN Complement DEPARTMENT OF IMMUNOLOGY

  22. Regulation of complement • Inactivated itself • Regulated by inhibitor DEPARTMENT OF IMMUNOLOGY

  23. DEPARTMENT OF IMMUNOLOGY

  24. Components of Immune Regulation • Immune system itself • Neuro-endocrine system DEPARTMENT OF IMMUNOLOGY

  25. Regulations by neuro-endocrine system DEPARTMENT OF IMMUNOLOGY

  26. Regulations by neuro-endocrine system DEPARTMENT OF IMMUNOLOGY

  27. Regulation of immune response Target cells Th1 CKs Tc MHC CK NK APC Ts Ag MHC CK Th2 CKs B Ab PMN Complement DEPARTMENT OF IMMUNOLOGY

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