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DENATURATION

DENATURATION. Environmental factors in a cell help determine the final shape of a polypeptide. Changes pH, temperature, ionic concentrations, etc., may unravel the protein or change its 3D shape by disrupting the bonds and interactions that hold it's tertiary structure .

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DENATURATION

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  1. DENATURATION • Environmental factors in a cell help determine the final shape of a polypeptide. • Changes pH, temperature, ionic concentrations, etc., may unravel the protein or change its 3D shapeby disrupting the bonds and interactions that hold it's tertiary structure. • Denaturation (loss of shape) also means a loss of function. http://diverge.hunter.cuny.edu/~weigang/Images/05-06_denaturation_1.jpg

  2. In some cases when the denaturing agent is removed, shape and function are regained (ie. Heat /chemical), unless the primary structure was disturbed. • Denaturation can be harmful: ex. prolonged fever...see pg 47. • Useful applications of denaturation: • curling/perming hair, • blanching fruits and veggies, • curing meat/veggies, • cooking food helps to break it down. • Other examples: thermophiles, gastrin,

  3. DENATURATION • Environmental factors in a cell help determine the final shape of a polypeptide. • Changes pH, temperature, ionic concentrations, etc., may ______________ __________________or change its 3D shapeby ______________________ _________________________________________ _________________________________________ • Denaturation (loss of shape) also means a ______________________________. http://diverge.hunter.cuny.edu/~weigang/Images/05-06_denaturation_1.jpg

  4. In some cases when the denaturing agent is __________________, shape and function are _______________ (ie. Heat /chemical), unless the primary structure was disturbed. • Denaturation can be __________________: ex. prolonged fever...see pg 47. • _____________ applications of denaturation: • _________________________________ • __________________________________ • __________________________________ • __________________________________ • Other examples: thermophiles, gastrin,

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