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1. 1/2NS 1000 ml IVD 4-6 hrs for hydration

GC. 1. 1/2NS 1000 ml IVD 4-6 hrs for hydration 2. Furosemide 20 mg IVA 10 min at the last 200 ml 1/2NS of hydration Dexamethasone 10 mg or Betamethasone 8 mg IVA 10 mins at 30 mins before chemotherapy

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1. 1/2NS 1000 ml IVD 4-6 hrs for hydration

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  1. GC 1. 1/2NS1000 ml IVD 4-6 hrs for hydration 2. Furosemide 20 mg IVA 10 min at the last 200 ml 1/2NS of hydration • Dexamethasone 10 mg or Betamethasone 8 mg IVA 10 mins at 30 mins before chemotherapy • Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy • Aprepitant cap 80 mg PO QD x 3 days • Gemcitabine 1200 mg/m2 in NS 100 ml IVD for 30 mins • Cisplatin 75 mg/m2 in NS 500 ml IVD for 2hr • 1/2NS 500ml IVD 2 hrs • If I>O more than 1500 ml or body weight increase over 1 kg per day, Furosemide 20 mg IVA 10 mins st ( Total IV volume: 1/2NS: 1500 ml, NS: 600 ml)

  2. GCar • 1. NS 500 ml IVDkeep line for chemotherapy • Dexamethasone 10 mg or Betamethasone 8mg IVA 10 mins at 30 • mins before chemotherapy • Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.oORGranisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mgIVA 10 mins at 15 mins before chemotherapy • 5.Gemcitabine 1200 mg/m2 in NS 100 ml IVD for 30 mins • 6. Carboplatin AUC =6 【dose=AUC X (CCr+25)】in NS 250 ml • IVD for 1 hr • 7. Run out the remaining NS • (Total IV volume: NS: 850ml)

  3. G 1. NS 500 ml IVDkeep line for chemotherapy • Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.oOR (自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy 5.Gemcitabine 1200 mg/m2 in NS 100 ml IVD for 30 mins 6. Run out the remaining NS ( Total IV volume: NS: 500 ml)

  4. NC (Q3W) • 1. 1/2NS 1000 ml IVD 4-6 hrs for hydration • Furosemide 20 mg IVA 10 mins at the last 200 ml 1/2NS of hydration • 3. Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy • Aprepitant cap 80 mg PO QD x 3 days • Vinorelbine 25 mg/m2 in NS 100 ml IVD for 10 mins • Cisplatin 75 mg/m2 in NS 500 ml IVD for 2 hr • 1/2NS 500 ml IVD 2 hrs • If I>O more than 1500 ml or body weight increase over 1 kg per day, • Furosemide 20 mg IVA 10 mins st • ( Total IV volume: 1/2NS: 1500 ml, NS: 600ml)

  5. NCar 1. NS 500 ml IVD keep line for chemotherapy 2. Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy 4.Vinorelbine 25 mg/m2 in NS 100ml IVD for 10 mins 5. Carboplatin AUC = 6【dose=AUC X (CCr +25)】in NS 250 ml IVD for 1 hr 6. Run out the remaining NS (Total IV volume: NS: 850ml)

  6. N 1. NS 500 ml IVDkeep line for chemotherapy • Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR (自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy 5. Vinorelbine 25 mg/m2 in NS 100 ml IVD for 10 mins 6. Run out the remaining NS ( Total IV volume: NS: 500 ml)

  7. Oral N+C 1. Vinorelbine (oral): 75 mg/m2 (30mg#, 20mg#) 2. 1/2NS1000 ml IVD 4-6 hrs for hydration 3. Furosemide 20 mg IVA 10 mins at the last 200 ml 1/2NS of hydration • Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy • Aprepitant cap 80 mg PO QD x 3 days • Cisplatin 75 mg/m2 in 500 ml NS IVD for 2 hr • 1/2NS 500ml IVD 2 hrs • If I>O more than 1500 ml or body weight increase over 1 kg per day, Furosemide 20 mg IVA 10 mins st ( Total IV volume: 1/2NS: 1500ml, NS: 500ml)

  8. Oral N+Carbo • Vinorelbine (oral): 75 mg/m2 (30mg #, 20mg #) • NS 500 ml IVD keep line for chemotherapy • Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy • Carboplatin AUC = 6【dose=AUC X (CCr +25)】in NS 250 ml IVD for 1 hr • Run out the remaining NS (Total IV volume: NS: 850ml)

  9. Oral N (Oral dose= IV dose x 2.5 ) 1. Vinorelbine (oral): 75 mg/m2 (30mg#, 20mg#)

  10. NC (Weekly) • 1. 1/2NS 500 ml IVD for hydration • Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mgIVA 10 mins at 15 mins before chemotherapy • Vinorelbine 25 mg/m2 in 1/2NS 100 ml IVD for 10 mins • Cisplatin 40 mg/m2 in NS 500 ml IVD for 2hr • 1/2NS 500 ml IVD for 2 hrs • If I>O more than 1500 ml or body weight increase over 1 kg per day, • Furosemide 20 mg IVA 10 mins st • ( Total IV volume: 1/2NS: 1000 ml, NS: 500ml)

  11. Q3W TaC • 1/2NS1000 ml IVD 4-6 hrs for hydration • Furosemide 20 mg IVA 10 mins at the last 200 ml 1/2NS of hydration 3. Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy 4 Chlorampheniramine 5 mg IVA 10 mins at 30 mins before chemotherapy 5 Ranitidine 50 mg or Famotidine 20 mg IVA 15 mins at 30 mins before chemotherapy • Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy • Aprepitant cap 80 mg PO QD x 3 days • Paclitaxel 175 mg/m2 in D5W 250 ml glass bottle x2 IVD with 0.22 um microfilter and NTG tube for 3 hrs ( if it is the first time, paclitaxel should be infused with EKG monitoring) • Cisplatin 75 mg/m2 in NS 500ml IVD for 2 hr • 1/2NS 500ml IVD 2 hrs • If I>O more than 1500 ml or body weight increase over 1 kg per day, Furosemide 20 mg IVA 10 mins st ( Total IV volume: 1/2NS: 1500 ml, NS: 500 ml, D5W: 250 ml x2)

  12. Q3W TaCarbo 1. NS 500 ml IVD keep line for chemotherapy 2. Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy 3 Chlorampheniramine 5 mg IVA 10 mins at 30 mins before chemotherapy 4 Ranitidine 50 mg or Famotidine 20 mg IVA 15 mins at 30 mins before chemotherapy 5 Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy 6. Paclitaxel 175 mg/m2 in D5W 250 ml glass bottle x2 IVD with 0.22 um microfilter and NTG tube for 3 hrs( if it is the first time, paclitaxel should be infused with EKG monitoring) 7. Carboplatin AUC = 6【dose=AUC X (CCr +25)】in NS 250 ml IVD for 1 hr 8. Run out the remaining NS ( Total IV volume: NS: 750 ml, D5W: 250 ml x2)

  13. Weekly Taxel 1. NS 500 ml IVD keep line for chemotherapy 2. Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy 3 Chlorampheniramine 5 mg IVA 10 mins at 30 mins before chemotherapy 4 Ranitidine 50 mg or Famotidine 20 mg IVA 15 mins at 30 mins before chemotherapy 5 Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR (自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy 6. Paclitaxel 80 mg/m2 in D5W 250 ml glass bottle IVD with 0.22 um microfilter and NTG tube for 1 hr( if it is the first time, paclitaxel should be infused with EKG monitoring) 7.Run out the remaining NS ( Total IV volume: NS: 500 ml, D5W: 250 ml)

  14. Weekly TaC 1. 1/2NS 1000 ml IVD 4-6 hrs for hydration 2. Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Chlorampheniramine 5 mg IVA 10 mins at 30 mins before chemotherapy • Ranitidine 50 mg or Famotidine 20 mg IVA 15 mins at 30 mins before chemotherapy • Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR(自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy 6. Paclitaxel 80 mg/m2 in D5W 250 ml glass bottle IVD with 0.22 um microfilter and NTG tube for 1 hr( if it is the first time, paclitaxel should be infused with EKG monitoring) 7. Cisplatin 25mg/m2 in NS 500ml IVD for 2 hr 8. 1/2NS 500ml IVD 2 hrs ( Total IV volume: 1/2NS: 1500 ml, NS: 500 ml, D5W: 250 ml)

  15. Taxotere+ Cisplatin, Q3W • 1/2NS 1000 ml IVD 4-6 hrs for hydration • Furosemide 20 mg IVA 10 mins at the last 200 ml 1/2NS of hydration • Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy • Aprepitant cap 80 mg PO QD x 3 days • Taxotere 60 mg/m2 in NS 250 ml IVD for 1 hr • Cisplatin 75 mg/m2 in NS 500 ml IVD for 2 hr • 1/2NS 500 mlIVD 2 hrs • If I>O more than 1500 ml or body weight increase over 1 kg per day, Furosemide 20 mg IVA 10 mins st ( Total IV volume: 1/2NS: 1500 ml, NS: 750 ml)

  16. Taxotere+ Carboplatin, Q3W • 1. NS 500 ml IVDkeep line for chemotherapy • Dexamethasone 10 mg or Betamethasone 8mg IVA 10 mins at 30 • mins before chemotherapy • Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.oORGranisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mgIVA 10 mins at 15 mins before chemotherapy • 5.Taxotere 60 mg/m2 in NS 250 ml IVD for 1 hr • 6.Carboplatin AUC =6 【dose=AUC X (CCr+25)】in NS 250 ml • IVD for 1 hr • 7. Run out the remaining NS • (Total IV volume: NS: 1000ml)

  17. Weekly Taxotere alone, Q3W • NS 500 ml IVDkeep line for chemotherapy • Dexamethasone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR(自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy 4. Docetaxel 40 mg/m2 in NS 250 ml IVD for 1 hr 5. Run out the remaining NS ( Total IV volume: NS: 500ml)

  18. Alimta, Q3W • NS 500 ml IVDkeep line for chemotherapy • Dexamethsone 10 mg or Betamethasone 8mg IVA 10 mins at 30 mins before chemotherapy • Metoclopramide 20 mg IVA 15 mins + Biperiden 2 mg p.o OR(自費) Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy 4. Pemetrexed 500 mg/m2 in NS 100ml IVD for 10 mins st 5. Run out the remaining NS ( Total IV volume: NS: 500ml)

  19. Cisplatin + VP-16 (EP) • 1. 1/2 NS 1000 ml IVD 4-6 hrs for hydration • 2. Furosemide 20 mg IVA × 10 mins at the last 200 ml NS of hydration • Dexamethasone 10 mg or Betamethasone 8 mg IVA 10 mins at 30 mins before chemotherapy • Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or alonosetron 0.25 mg IVA × 10 mins at 15 mins before chemotherapy • Aprepitant cap 80 mg PO QD x 3 days • Cisplatin 75 mg/m2 in NS 500 ml IVD × 2 hr • Etoposide (VP-16) 75 mg/m2 in NS 500 ml IVD × 2 hrs • 1/2NS 500 mlIVD 2 hrs • If I>O more than 1500 ml or body weight increase over 1 kg per day, Furosemide 20 mg IVA 10 mins st ( Total IV volume: 1/2 NS: 1500 ml, NS: 1000 ml)

  20. Carboplatin + VP-16 (CarE) 1. NS 500 ml IVD keep line for chemotherapy 2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30 mins before chemotherapy 3. Metoclopramide 20 mg IVA × 15 mins at 15 mins before chemotherapy 4. Carboplatin AUC =6 【dose=AUC X (CCr+25)】in NS 250 ml IVD for 1 hr 5. Etoposide (VP-16) 75 mg/m2 in NS 500 ml IVD × 2hrs 6. Run out the remaining NS ( Total IV volume: NS: 1500ml)

  21. VP-16 (E) 1. NS 500 ml IVDkeep line for chemotherapy 2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30 mins before chemotherapy 3. Metoclopramide 20 mg IVA 10 mins at 15 mins before chemotherapy 4. Etoposide (VP-16) 75 mg/m2 in NS 500 ml IVD × 2 hrs 5. Lorazepam 1 mg p.o. hs 6. Run out the remaining NS ( Total IV volume: NS: 1000ml)

  22. Oral VP-16 (Oral E) • Oral Etoposide 50mg QD × 10 days

  23. Ifosfamide (I) 1. NS 500 ml IVDkeep line for chemotherapy 2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30 mins before chemotherapy 3. Metoclopramide 20 mg IVA × 15 mins at 15 mins before chemotherapy 4. Ifosfamide 1000 mg/m2 in NS 500 ml IVD × 2hrs 5. Uromitexan 400mg add in NS 100 ml for IVD× 30 mins q2h × 3 doses (at 0,2,4 hrs after Ifosfamide) 6. Lorazepam 1 mg hs ( Total IV volume: NS: 2000ml)

  24. Topotecan + Epirubicin (TE) 1. NS 500 ml IVDkeep line for chemotherapy 2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30 mins before chemotherapy 3. Metoclopramide 20 mg IVA × 15 mins at 15 mins before chemotherapy 4. Topotecan 1.5 mg/m2 IVD in NS 100 ml × 30 mins 5. Epirubicin 30 mg/m2 in NS 500 ml IVD× 2 hrs 6. Run out the remaining NS ( Total IV volume: NS: 1000ml)

  25. Topotecan (T) 1. NS 500 ml IVDkeep line for chemotherapy 2. Dexamethasone 10 mg or Betamethasone 8 mg IVA × 10 mins at 30 mins before chemotherapy 3. Metoclopramide 20 mg IVA × 15 mins at 15 mins before chemotherapy 4. Topotecan 1.5 mg/m2 IVD in NS 100 ml × 30 mins 5. Run out the remaining NS ( Total IV volume: NS: 500 ml)

  26. Pemetrexed + Cisplatin (Q3W) • 1/2NS 1000 ml IVD 4-6 hrs for hydration • Furosemide 20 mg IVA 10 min at the last 200 ml 1/2NS of hydration • Dexamethasone 10 mg or Betamethasone 8 mg IVA 10 mins at 30 mins before chemotherapy • Granisetron 3 mg or Tropisetron 5 mg or Ondansetron 16 mg or Palonosetron 0.25 mg IVA 10 mins at 15 mins before chemotherapy • Aprepitant cap 80 mg PO QD x 3 days • Pemetrexed 500 mg/m2inNS 100 ml IVD for 10 mins • Cisplatin 75 mg/m2inNS 500 ml IVD for2 hrs • 1/2 NS 500ml IVD 2 hrs • If I>O more than 1500 ml or body weight increase over 1 kg per day, furosemide 20 mg IVA 10 mins st • (Total IV volume: 1/2NS: 1500 ml, NS: 600 ml)

  27. Pemetrexed + Carboplatin (Q3W) 1. NS 500 ml IVD keep line for chemotherapy 2. Dexamethasone 10 mg or Betamethasone 8 mg IVA 10 mins at 30 mins before chemotherapy 3. Metoclopramide 20 mg IVA 15 mins and biperiden 2 mg po st before chemotherapy 4. Pemetrexed 500 mg/m2inNS 100 ml IVD for 10 mins 5. Carboplatin AUC=6inNS 250 ml IVD for1 hr 6. Run out the remaining NS (Total IV volume: NS 850 ml)

  28. 關Aloxi健保給付如下 • 7.2.1 serotonin antagonists（如ondansetron、granisetron、tropisetron、ramosetron、palonosetron (Aloxi)等）(93/2/1、93/9/1、98/9 /1、99/5/1)1.血液幹細胞移植患者接受高劑量化學治療時。2.惡性腫瘤患者及風濕免疫疾病（如紅斑性狼瘡、類風濕性關節炎、貝西氏症、皮肌炎/多發性肌炎、硬皮症、血管炎等）患者接受化學治療時，依下述情形使用：(98/9 /1、99/5/1)(1)前述患者處方高致吐性藥品，可預防性使用ondansetron 8~32mg、granisetron 1~3mg、tropisetron 5mg、ramosetron 0.3mg一日劑量。必要時，其使用以不得超過5日為原則。若發生嚴重延遲性嘔吐，得直接使用，每療程使用不得超過5日為原則。(2)前述患者處方中致吐性藥品，可預防性使用ondansetron 8~32mg、granisetron 1~3mg、tropisetron 5mg、ramosetron 0.3mg一日劑量。若發生嚴重延遲性嘔吐，使用dexamethasone 及 metoclopramide 無效之病例，每療程使用以不得超過5日為原則。病歷須有使用dexamethasone及 metoclopramide 無效之紀錄。(3) 血液腫瘤病患接受化學治療，須使用中、高致吐性抗癌藥品時，得依患者接受抗癌藥品實際使用天數使用本類製劑。(93/9/1)(4) Palonosetron限於中、高致吐化學治療之前使用。(99/5/1) • 1. 高致吐性藥品：cisplatin (>50mg/m2/day)，carmustine (≧250mg/m2 /day)，cyclophosphamide (>1500mg/m2/day)，methotrexate (≧1.2gm/m2/day)。 • 2. 中致吐性藥品：cisplatin (≧30mg/m2/day, ≦50mg/m2/day)，carmustine (<250mg/m2/day)，Cyclophosphamide (≦1500mg/m2 /day)，doxorubicin (≧45mg/m2/day)，epirubicin (≧70mg/m2/day)，CPT-11，idarubicin (≧10mg/m2/day)，daunorubicin (≧60mg/m2 /day)，dactinomycin (actinomycin-D)，arsenic trioxide，melphalan (≧50mg/m2/day)，cytarabine，carboplatin，oxaliplatin，ifosfamide，mitoxantrone，dacarbazine且其使用劑量為一般公認治療劑量或上述規定劑量時。 • 所以原則上Aloxi在carboplatin也有給付

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