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Understanding Supporting Tissues in Cartilage and Bone Biology

Explore the functions, structures, and origins of supporting tissues such as cartilage and bone. Learn about cells, extracellular matrix, types of cartilage, and proteoglycans in this comprehensive guide.

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Understanding Supporting Tissues in Cartilage and Bone Biology

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  1. Supportingtissues: cartilage and bone Anna L. Kiss Department of Anatomy, Histology and Embryology Semmelweis University Budapest 2018

  2. Supportingtissue • Function: supportsthe body • Structure: cells + extracellularmatrix • Origin: mesoderm • Types: cartilage bone

  3. Cartilage CellsExtracellularmatrix chondroblasts chondrocytes osteoblasts osteocytes osteoclasts groundsubstance fibers

  4. Cells + extracellularmatrix • Cells: chondrocytes • Extracellularmatrix: fibers (collagen, elastic) + groundsubstance proteoglycans glycoproteins: chondrocalcin, cartilagematrix protein (CMP), chondronectinfibronectin

  5. Extracellularmatrix • Proteoglycanes+adhesionmolecules • filamentuosmolecules: 3 dimensionalnetwork – gelatinuosmaterial • is abletobindlargeamount of water – flexibility (turgor)

  6. GAG: • Hyaluronicacid: glucuronicacid + N-acetilglucosamin • Chondroitinsulfate: N-acetyl-galactosamin • Keratansulfate: N-acetyl-glucosamin + sulfatedgalactose Proteoglycane: „core” protein + chondroitinsulfate and keratansulfate

  7. Proteoglycan GAG chains HA-binding region Core protein hyaluronic acid link protein

  8. Types of cartilage • Hyalin: functional unit: chondron: coversthebonysurfaces of thejoints • Elastic • Fibrous: intervertebraldisc, temporomandibularjoint

  9. chondroblasts

  10. Chondron: chondrocytes basophylic capsule territorial matrix

  11. hyalin cartilage

  12. elastic cartilage

  13. fibrous cartilage

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