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Mus musculus

Mus musculus. 85% homology with human DNA Genome of appx. 3 million base pairs. Xenoturburelli. No brain, spine, gut or sex organs ~50% homology with humans. Musa acuminata. 50% Homology With Humans. Drosophila melanogaster. 44% Homology With Humans

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Mus musculus

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  1. Mus musculus • 85% homology with human DNA • Genome of appx. 3 million base pairs

  2. Xenoturburelli • No brain, spine, gut or sex organs • ~50% homology with humans

  3. Musa acuminata • 50% Homology With Humans

  4. Drosophila melanogaster • 44% Homology With Humans • Shares many similar disorders with humans including insomnia

  5. Saccharomyces cerevisiae • 26% Homology With Humans • Share the same genes responsible for breast cancer

  6. Escherichia coli • 7% Homology With Humans • Harmful strains have 1300 genes; harmless have only 530 genes

  7. Phylogeny • Def: The Evolutionary History of A Species

  8. Evidence For Evolution • Fossil Evidence • Homologous Structures • Analogous structures show convergence • Embryological Similarities • Biochemical Similarities • DNA Homology

  9. Cytochrome C Homology cow tuna

  10. cow Tuna

  11. How Did Modern Humans Evolve?

  12. General Primate Characteristics • Mammals • Large cerebral volume • Binocular vision • Rotatating forearms & shoulder sockets • Opposable digits

  13. Why have primates diverged over the last 65 million years?

  14. Prosimians • First group of mammals with primate characteristics • Adapted for habitat & niche in trees

  15. Tectonic Shifts 65mya to present

  16. New v. Old World Monkeys • Due to continental drift and competition, primates diverge into two smaller factions • Old World (African) • New World (South American) • Despite name, old world monkeys include apes, chimps and orangutans

  17. Miocene Changes & Old World Monkeys • Cool weather appx 23.7 mya causes drastic reduction in size of rainforest biome • Increased competition among Old World monkeys • Those with variations to stand upright are favored for survival on savannah

  18. “Monkeys” v. “Apes”? • True monkeys diverge from apes 8 million years ago • Apes diverge into two subgroups • Chimp/Gorilla • Southern Apes

  19. “Lumpers” The chimps, apes and hominoids all diverged at the same time “Splitters” Chimps and apes diverged first Hominoids diverged from chimps later Which Model Is Supported?

  20. Lab: Proving Primate Phylogeny via DNA Hybridization of the RH1

  21. Using the RH Factor As Evolutionary Evidence • Among primates, there is variance between the DNA sequences in the introns that are part of the Rh1 blood factor • By hybridizing DNA from the Rh1 intron with cDNA from a related species, we can determine which species have diverged most recently.

  22. Protocol • 1) On your table, you should have five models of DNA and cDNA sequences • Human DNA Template of Rh1 Intron • Human cDNA for Rh1 Intron • Chimpanzee cDNA for Rh1 Intron • Gorilla cDNA for Rh1 Intron • Paranthopus DNA Template for Rh1 Intron • 2) In each model the following colors represent various nucleotides • Adenine = Black • Cytosine = Red • Guanine = Yellow • Thymine = Blue

  23. Protocol • 3) Make the following comparisons and record how many nucleotides are incorrectly paired (i.e. A-G, C-T, etc.)

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