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Viral infections of the respiratory tract. BRSV IBR ParainfluenzaBVDVAdenovirusesMaedi-Visna. Infectious Bovine Rhinotracheitis - IBR. Acute disease of upper resp. tractFever, keratoconjunctivitis, nasal and occular discharge, explosive cough, salivationNon-complicated disease lasts 10-14 da
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1. Infections of ruminants
2. Viral infections of the respiratory tract BRSV
IBR
Parainfluenza
BVDV
Adenoviruses
Maedi-Visna
3. Infectious Bovine Rhinotracheitis - IBR Acute disease of upper resp. tract
Fever, keratoconjunctivitis, nasal and occular discharge, explosive cough, salivation
Non-complicated disease lasts 10-14 days
Frequent secondary infections (Pasteurella)
4. IBR - diagnostics Izolation on TC
Typization by monoclonal antibodies
Seroconversion (dynamique)
5. BRSV Main pathogen in the respiratory complex
Affects young age category
High incidence of the disease, mortality up to 20% (bacterial coinfections)
Biphasic disease curve
Colostral antibodies doesn´t protect against infection
6. BRSV - diagnostics Very labile virus, izolation on TC not reliable
Antigen capture ELISA
IF test
Detection of VN antibodies (paired samples)
Calf with colostral antibodies doesn´t seroconvert
7. THE RESPIRATORY TRACT
8. THE RESPIRATORY TRACT
9. Infection of GIT BVDV
Bovine Coronavirus
Bovine Rotavirus
Some serotypes of adenoviruses
10. Coronavirus skotu Primary pathogen
Disease of 3-21 day old calf, sometimes in older animals (up to 3 months)
Watery diarrhoea, dehydratation, acidosis…
Virus replication in distant part of the gut, desquamation, malabsorption syndrome
Enzootic disease, prevalence up to 100%
11. Bovine Coronavirus - diagnostics Virus shedding stops after exfoliation of infected enterocytes
IF detection
smears
Sections of the gut
Antigen capture ELISA
Immunoelectron microscopy
Isolation on TC (some strains only, long lasting)
HA test
12. Bovine Coronavirus - diagnostics Detection of antibodies
Ab are virtually in all animals
Dynamics of seroconversion (IgM or IgA)
13. Bovine Rotavirus Primary pathogen, endemic
Calfs -1-2 weeks (then subclinical course)
Diarrhoea
Milder course than in coronaviruses, same pathogenesis
At least 3 serotypes
No cross protection
14. Bovine Rotavirus - diagnostics IEM
IF test
Cell line MA104 – IF confirmation
ELISA kits
Latex agglutination test
Antibody detection- high serological prevalence
15. THE ALIMENTARY TRACT actinobacilosis (soft tissues infection)
Actinobacillus lignieresii benzylpenicillin i.v.,i.m.
actinomycosis (bone infection)
Actinomyces bovis benzylpenicillin i.m.
16. THE ALIMENTARY TRACT enteritis/enterotoxicosis/enterotoxemia
E. coli (F5)
calves less than 1 w. colistin p.o inact. vac. s.c.
Salmonella Enteritidis, S. Typhimurium
calves 1-5 w enrofloxacin p.o.
C. perfringens typ A,C
calves tylosin i.m. inact. vac. s.c.
Salmonella Typhimurium
feed lot enrofloxacin i.m., p.o.
Salmonella Dublin cephalosporines 1.-3.g i.v.,i.m.
17. Infection of genital tract IBR
BVDV
Scrapie
18. THE URINARY TRACT
19. THE REPRODUCTIVE SYSTEM
20. THE REPRODUCTIVE SYSTEM
21. MAMMARY GLAND - MASTITIS
22. Infection of CNS Maedi-Visna
CAEV
IBR
BVDV
BSE
Scrapie
23. THE CENTRAL NERVOUS SYSTEM
24. THE EYE
25. Skin Infections Bovine Papillomavirus
Bovine poxvirus
Ovine poxvirus
Herpesvirus - mamilitis
26. THE SKIN