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CHMI 2227E Biochemistry I

CHMI 2227E Biochemistry I. Proteins: Tertiary structure. Tertiary structure. Collagen. myoglobin. Tertiary structure. http:// butane.chem.uiuc.edu/cyerkes/chem104A_S07/Lecture_Notes_104/lect28c.html. Tertiary structure Interaction forces.

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CHMI 2227E Biochemistry I

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  1. CHMI 2227EBiochemistry I Proteins: Tertiary structure CHMI 2227 - E.R. Gauthier, Ph.D.

  2. Tertiary structure CHMI 2227 - E.R. Gauthier, Ph.D.

  3. Collagen myoglobin Tertiary structure CHMI 2227 - E.R. Gauthier, Ph.D.

  4. http://butane.chem.uiuc.edu/cyerkes/chem104A_S07/Lecture_Notes_104/lect28c.htmlhttp://butane.chem.uiuc.edu/cyerkes/chem104A_S07/Lecture_Notes_104/lect28c.html Tertiary structureInteraction forces CHMI 2227 - E.R. Gauthier, Ph.D. Check this one out: http://www.elmhurst.edu/~chm/vchembook/567tertprotein.html

  5. Tertiary structure A B CHMI 2227 - E.R. Gauthier, Ph.D.

  6. Tertiary structureFolding motifs - 1 CHMI 2227 - E.R. Gauthier, Ph.D.

  7. Tertiary structureFolding motifs - 2 CHMI 2227 - E.R. Gauthier, Ph.D.

  8. Domain 1 Domain 2 Domain 3 Tertiary structureProtein domains – Pyruvate kinase CHMI 2227 - E.R. Gauthier, Ph.D.

  9. b-turn b-turn Proline Tertiary structure1. Myoglobin CHMI 2227 - E.R. Gauthier, Ph.D.

  10. Hydrophilic amino acids: Blue Hydrophobic amino acids: Yellow Cross-sectional view Tertiary structure1. Myoglobin CHMI 2227 - E.R. Gauthier, Ph.D.

  11. Hydrophilic amino acids: Blue Hydrophobic amino acids: Yellow Tertiary structure2. Porin – a membrane-bound protein CHMI 2227 - E.R. Gauthier, Ph.D.

  12. Tertiary structureChaperones CHMI 2227 - E.R. Gauthier, Ph.D.

  13. Tertiary structureProtein denaturation CHMI 2227 - E.R. Gauthier, Ph.D. Check this one out: http://www.elmhurst.edu/~chm/vchembook/568denaturation.html

  14. Tertiary structureProtein denaturation CHMI 2227 - E.R. Gauthier, Ph.D.

  15. Examples of proteins1. Green fluorescent protein CHMI 2227 - E.R. Gauthier, Ph.D.

  16. Light! Examples of proteins1. Green fluorescent protein CHMI 2227 - E.R. Gauthier, Ph.D.

  17. Golgi apparatus Nucleus Examples of proteins1. Green fluorescent protein CHMI 2227 - E.R. Gauthier, Ph.D.

  18. Examples of proteins1. Green fluorescent protein CHMI 2227 - E.R. Gauthier, Ph.D.

  19. Toxic form = PrPsc http://en.wikipedia.org/wiki/Image:Prion.gif Normal form = PrPc Examples of proteins2. Prion proteins CHMI 2227 - E.R. Gauthier, Ph.D.

  20. Examples of proteins2. Prion proteins Fiber aggregation CHMI 2227 - E.R. Gauthier, Ph.D.

  21. Important web site:http://www.pdb.org/pdb/home/home.do CHMI 2227 - E.R. Gauthier, Ph.D.

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