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Obesity Management: Lifestyle Modification/Bariatric Surgery

This study compares the effectiveness of different diets in achieving weight loss over a 12-month period, with a focus on lifestyle modification and bariatric surgery. Researchers identified the glycemic burden, postprandial hyperglycemia, and factors impacting metabolic health. The study highlights postprandial physiology, insulin action, anti-inflammatory effects, and the benefits of insulin in acute illness. Results emphasize the significance of maintaining balance and managing conditions like cardiovascular disease, coagulation, and oxidative stress. Insights on adiposity, adipokines, and the role of adipose tissue in endocrine function are also discussed.

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Obesity Management: Lifestyle Modification/Bariatric Surgery

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  1. Obesity Management:Lifestyle Modification/Bariatric Surgery

  2. Comparison of Diets:12-Month Weight Lossa b Zone n=79 LEARN n=79 Ornish n=76 b b Atkins n=77 Weight Loss (kg)

  3. Chief, Division of Diabetes,Endocrinology and Metabolism Mark Collie Professor of Medicine and Molecular Physiology and Biophysics Stephen N. Jones, MD, FRCP

  4. Identifying the Glycemic Burden 24-Hour Glucose Fasting Preprandial Postprandial Hepatic glucose output Bolus insulin secretion Glucosedisposal

  5. Why Care about Postprandial Hyperglycemia (PPHG)? CVD Coagulation Hyper TG PPHG Microvascular disease Oxidative Stress Oxidized LDL Increased Inflammatory Markers

  6. Maintaining Balance:Postprandial Physiology and the Pathogenesis of Disease John Davis, MD, FRCP Chief, Diabetes, Endocrinology and Metabolism Jack CollieProfessor of Medicine, Molecular Physiology and Biophysics

  7. Current View of the Action of Insulin Anti-inflammatory NF-KB, IkB, MCP-1,ICAM-1, CRP Antithrombotic TF, PAI-1 Antioxidant ROS Mechanism of the benefit of insulin in acute illness Vasodilation andplatelet inhibition NO release, cAMP,eNOS Cardioprotective Neuroprotective Anti-apoptotic Glucose lowering

  8. Abdominal Adiposity There is No Time to Weight Michael Black, M.D. Mayo College of Medicine

  9. FFA and Obesity * * mol/L mol•kg LBM-1•min-1

  10. Leptin Angiotensinogen Adipocyte RBP- 4 Resistin IL-6 Adipsin (ASP) Visfatin Adipose Tissue as Endocrine Cells Insulin sensitivity Improved metabolism Adiponectin

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