1 / 41

PHARMACOLOGY

PHARMACOLOGY. PHARMACOLOGY. THE STUDY OF DRUG ACTIONS ON AND INTERACTIONS WITH LIVING ORGANISMS. PHARMACOKINETICS. THE INTERACTIONS OF DRUGS WITH BODY TISSUES. SYSTEMIC ADMINISTRATION OF DRUG. ABSORPTION DISTRIBUTION BIOTRANSFORMATION EXCRETION. ABSORPTION.

london
Download Presentation

PHARMACOLOGY

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PHARMACOLOGY

  2. PHARMACOLOGY • THE STUDY OF DRUG ACTIONS ON AND INTERACTIONS WITH LIVING ORGANISMS.

  3. PHARMACOKINETICS • THE INTERACTIONS OF DRUGS WITH BODY TISSUES

  4. SYSTEMIC ADMINISTRATION OF DRUG • ABSORPTION • DISTRIBUTION • BIOTRANSFORMATION • EXCRETION

  5. ABSORPTION • IN ORDER FOR THE DRUG TO PRODUCE DESIRED EFFECTS ON THE BODY, IT MUST REACH THE INTENDED SITE OF ACTION!!!! DRUG ABSORBED AND CIRCULATIONG IN THE BLOODSTREAM IS CALLED BIOAVAILABLE

  6. DISTRIBUTION • FOLLOWING ABSORPTION DRUGS ARE DISTRIBUTED VIA CIRCULATORY SYSTEM.

  7. BIOTRANSFORMATION • MOST DRUGS ARE METABOLIZED IN THE LIVER AND EITHER REDUCED OR CHANGED INTO A WATER-SOLUABLE SUBSTANCE SO THEY CAN BE EXCRETED BY KIDNEYS

  8. EXCRETION • MOST DRUGS ARE EXCRETED BY KIDNEYS. OTHER EXCRETION ROUTES: PERSPIRATION, TEARS, FECES, BREAST MILK, SALIVA

  9. FACTORS THAT INFLUENCE DRUG ADMINISTRATION • AGE • GENDER • HORMONAL DIFFERENCES • EMOTIONAL OR PSYCHOLOGICAL STATE • TIME OF DAY • THE CHANNEL OR ROUTE OF ADMINISTRATION

  10. DRUG ADMINISTRATION ROUTES • ORAL • TOPICAL • PARENTERAL • SUBLINGUAL • INTRATHECAL • RECTAL • TRANSDERMAL • INHALATION

  11. ORAL DRUG ADMINISTRATION

  12. Advantages • Base (cream, ointment, gel, spray) makes application easy and controllable. • Onset of symptom relief is usually faster than oral preparations. • Symptoms are relieved at a steady rate and relief may last longer. • A smaller amount of medicine may be needed when applied in a topical form. • Formulations diffuse through the skin and enter the bloodstream, initially bypassing the digestive system (called 'first pass'). Many systemic (whole body) side effects, such as irritated stomach lining, may be lessened or eliminated TOPICAL DRUGS

  13. PARENTERAL DRUG ADMINISTRATION • SUBCUTANEOUS • INTRAMUSCULAR • INTRAVENOUS

  14. For the subcutaneous route, a needle is inserted into fatty tissue just beneath the skin. The drug is injected, then moves into small blood vessels (capillaries) and is carried away by the bloodstream or reaches the bloodstream through the lymphatic vessels. SUBCUTANEOUS

  15. The intramuscular route is preferred to the subcutaneous route when larger volumes of a drug product are needed. Because the muscles lie below the skin and fatty tissues, a longer needle is used. Drugs are usually injected into muscle in the upper arm, thigh, or buttock. How quickly the drug is absorbed into the bloodstream depends, in part, on the blood supply to the muscle: The sparser the blood supply, the longer the drug takes to be absorbed. The blood supply is increased during physical activity INTRAMUSCULAR

  16. INTRAVENOUS Intravenous injecting is a highly efficient way of introducing drugs into the body. However, when drugs are injected, the filtering and delaying mechanisms that protect us when things are absorbed via the gastro-intestinal tract, lungs or skin are bypassed. The potential for infection and overdose are much increased

  17. Sublingual Route A few drugs are placed under the tongue (taken sublingually) so that they can be absorbed directly into the small blood vessels that lie beneath the tongue. The sublingual route is especially good for ANGINA—which is used to relieve angina (chest pain due to an inadequate blood supply to the heart muscle)—because absorption is rapid and the drug immediately enters the bloodstream without first passing through the intestinal wall and liver. However, most drugs cannot be taken this way because they may be absorbed incompletely or erratically SUBLINGUAL

  18. For the intrathecal route, a needle is inserted between two vertebrae in the lower spine and into the space around the spinal cord. The drug is then injected into the spinal canal. A small amount of local anesthetic is often used to numb the injection site. This route is used when a drug is needed to produce rapid or local effects on the brain, spinal cord, or the layers of tissue covering them (meninges)—for example, to treat infections of these structures. Anesthetics are sometimes given this way. INTRATHECAL

  19. Rectal Route Many drugs that are administered orally can also be administered rectally as a suppository. In this form, a drug is mixed with a waxy substance that dissolves or liquefies after it is inserted into the rectum. Because the rectum's wall is thin and its blood supply rich, the drug is readily absorbed. A suppository is prescribed for people who cannot take a drug orally because they have nausea, cannot swallow, or have restrictions on eating, as is required after many surgical operations. Drugs that are irritating in suppository form may have to be given by injection RECTAL

  20. TRANSDERMAL Drugs can be administered transdermally by a patch applied to the skin. The drug penetrates the skin and is absorbed into the bloodstream.

  21. INHALATION Drugs can be administered using inhalers, which deliver the drugs directly to the airways

  22. ADVERSE EFFECTS OF DRUGS • AN UNINTENDED EFFECT THAT IS EXPECTED TO OCCUR IS CALLED: • SIDE EFFECT • ANY EFFECT THAT IS NOT BENIGN IS CALLED AN ADVERSE REACTION

  23. DRUGS INCOMPATIBILITY • WHEN MIXED SOME DRUGS CAN BECOME EITHER TOXIC OR INACTIVE!!!!!

  24. RT HAS AN OBLIGATION: • TO KNOW THE LOCATION OF THE EMERGENCY CART. • TO SUMMON EMERGENCY HELP IN TIMELY MANNER • TO MAINTAIN COMPLETENESS OF THE EQUIPMENT ON THE EMERGENCY CART

  25. EMERGENCY CART

  26. DRUG NAMES • TRADE NAME • CHEMICAL NAME • GENERIC NAME • OFFICIAL NAME

  27. TRADE NAME • NAME ASSIGNED BY THE MANUFACTURER

  28. CHEMICAL NAME • EXACT CHEMICAL FORMULA

  29. GENERIC NAME • GIVEN BEFORE THE OFFICIAL APPROVAL FOR USE

  30. OFFICIAL NAME • GENERIC AND OFFICIAL NAMES ARE USUALLY THE SAME • USED IN THE OFFICIAL PUBLICATIONS

  31. DRUG CLASSIFICATIONS • ANT-INFECTIVE • ACTING ON THE NERVOUS SYSTEM • ANALGESICS • ANTIPYRETICS • TO TREAT CARDIO-VASCULAR DISEASE • TO TREAT GI • TO TREAT ALLERGIC RESPONSES

  32. ANTI-INFECTIVE • ANTIBIOTICS- (PENICILLIN, ERYTHROMYCIN)

  33. ACTING ON THE NERVOUS SYSTEM • CHLORAL HYDRATE – SEDATIVE- ORAL, RECTAL • MORPHINE SULFATE – CONTROL OF SEVERE PAIN- ORAL, PARENTERAL • LIDOCAINE – ANESTHETIC- PAIN BLOCKER – TOPICAL, PARENTERAL

  34. ANALGESICS,ANTIPYRETICS, ANTI-INFLAMMATORY • ASPIRIN • ACETOMINOPHEN • IBUPROFEN ORAL

  35. TO TREAT CARDIOVASCULAR DISEASE • LASIX- ( DIURETIC ACTION)- IV, ORAL • HEPARIN - IV AND COUMARIN- (ANTICOAGULANTS) ORAL • NITROGLYCERIN – (VASODILATOR) ANGINA PECTORIS – SUBLINGUAL, TOPICAL

  36. TO TREAT GI • SODIUM BICARBONATE pH ORAL • CASTOR OIL- CATHARTIC- ORAL • MILK OF MAGNESIA- CATHARTIC-ORAL

  37. TREATMENT OF ALLERGIC RESPONSES • EPINEPHRINE (ADRENALIN)- BRONCHODILATOR-VASOCONSTRICTOR-PARENTERAL , INHALATION • BENADRYL – ORAL , PARENTERAL

More Related