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Stem cell technologies Current state Future promise

Proposition 71: Purpose and Intent. Create California Institute for Regenerative Medicine.Oversight by Independent Citizen's Oversight Committee (ICOC).Support the development of technologies involving pluripotent stem cell and progenitor cell.Prohibit human reproductive cloning. . Proposition

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Stem cell technologies Current state Future promise

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    1. Stem cell technologies Current state Future promise Where UCI fits in to the Post Prop. 71 world of biotechnology development in California

    2. Proposition 71: Purpose and Intent Create California Institute for Regenerative Medicine. Oversight by Independent Citizen’s Oversight Committee (ICOC). Support the development of technologies involving pluripotent stem cell and progenitor cell. Prohibit human reproductive cloning

    3. Proposition 71: Funds Funding details Authorizes an average of $295 million per year in bonds over a 10-year period, $3 billion total In any year, no more than $350 million in bonds to be issued If less than $350 million is issued in any year, the remaining permitted amount may be carried over to one or more subsequent years

    4. Proposition 71: Research facilities

    5. Proposition 71: Oversight The ICOC must meet in an open meeting format. Closed sessions may be conducted when discussing: Matters involving information relating to patients or medical subjects. Matters involving confidential intellectual property or work product Matters involving prepublication, confidential scientific research or data Matters concerning the appointment, employment, performance, compensation, or dismissal of institute officers and employees

    6. Proposition 71: Scientific and Medical Working Groups Scientific and Medical Research Funding Working Group. Scientific and Medical Accountability Standards Working Group. Scientific and Medical Research Facilities Working Group.

    13. The vision for UCI’s Stem Cell Center: Stem cell therapies for neurological disorders Brain and spinal cord injury. Stroke. Neurodegenerative diseases Parkinson’s Disease Huntington’s Disease Alzheimer’s Disease Multiple Sclerosis Lou Gerhig’s Disease (ALS)

    14. Neurological disorders involve the loss of particular cell types in the nervous system Brain and spinal cord injury and stroke (loss of nerve cells and myelin-forming oligodendrocytes). Neurodegenerative diseases Parkinson’s Disease (loss of dopamine-containing nerve cells in the brainstem). Huntington’s Disease (loss of nerve cells in the striatum). Alzheimer’s Disease (loss of nerve cells in the cerebral cortex). Multiple Sclerosis (loss of myelin-forming oligodendrocytes). Lou Gerhig’s Disease-ALS (loss of motor neurons from the spinal cord). The vision: To use embryonic stem cells to restore the cells that are lost as a result of injury or neurodegenerative diseases.

    17. At the RIRC, a therapy is being developed to use stem cells to replace myelin-forming cells

    19. But do these cells have the potential to form tumors over longer periods of time?

    21. Developing facilities for stem cell research

    22. Proposition 71: Funds

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