Leptin

1. Leptin By: Matthew, Matias, Frank, Julian 5/14/13 Biology Period 4

2. Where is leptin? • Leptin is a hormone in the endocrine system. • Leptin is know for losing obesity the hormone role is to make you feel full after eating a meal. • Quoted by: Livestrong.com

3. Where is leptin produced? • Leptin is produced by adipose tissue. • Adipose tissue is known as “Fat”. • Leptin is a "peptide hormone," meaning it is made of proteins. • A gene code in the adipose cells handles the making of the leptin hormone, and for making sure there is enough of leptin awaiting to go into the bloodstream. • Quoted by: LIVESTRONG.COM and sciencedaily.com

4. When Leptin is released into the bloodstream. • Leptin is released into the bloodstream shortly after eating, aiming for its target tissues, most significantly, portions of the brain that control feeding • Leptin must cross the blood-brain barrier in order to locate its target tissues. Once it does, desire to eat should cease. • Quoted by: LIVESTRONG.COM

5. Where leptin activity in other places to. • The relationship of chronic diseases such as obesity to leptin activity in the brain, leptin receptors also have been located in the lungs, kidneys, liver, pancreas and skeletal muscle. • Quoted by: LIVESTRONG.cOM

6. The clinical uses of leptin. • Those with low leptin activity in their brain may want a supplemental form of this "anti-obesity" hormone, but no such drug or product exists. • Even if an oral supplement were marketed, because leptin is a peptide (protein-based) hormone, it would be disassembled by chemical digestion in the stomach and small intestine. • There is a solution, however, and that is weight loss. Evidence published in the February 2008 issue of “Nutrient" verified previous findings that losing weight reduces the size of fat cells, and subsequently, less leptin is released. Lowered circulating leptin improves leptin activity in the brain.

7. Fin