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GENOMICS AS AN INTER-AND TRANS-DISIPLINARY SCIENCE

GENOMICS AS AN INTER-AND TRANS-DISIPLINARY SCIENCE. David Conti Dept. of Preventive Medicine. Phenotype. Conventional Paradigm:. Single, rare, highly penetrant. Little interaction with other genes or environment. Use family data. Well defined. Rare.

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GENOMICS AS AN INTER-AND TRANS-DISIPLINARY SCIENCE

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  1. GENOMICS AS AN INTER-AND TRANS-DISIPLINARY SCIENCE David Conti Dept. of Preventive Medicine Phenotype Conventional Paradigm: • Single, rare, highly • penetrant. • Little interaction with other • genes or environment. • Use family data. • Well defined. • Rare. • High Familial Aggregation. Genes

  2. New Paradigm: Social, Culture, and Economic Context Environment (Diet, exercise, etc…) Smoking Initiation And Progression Intervention/ Prevention Program Personal Characteristics Dispositional Attributes Physical Attributes Genes Genes Environment Environment

  3. Mechanistic Approach to Molecular Epidemiology

  4. Complex Gene Structure and Variation GCTAGATTCAGGCCCAGTTAAAGCACAGGGTGAGTTATTCCTCTGTGACATTCTTTTGTCACCAAGGGGTCTTGTTAGAGAGGCGGTTAATGCCAGCTGATATATATATTATTCAAAGGTAGGGCTCAAGGTGTGATCTGAGGTTTTTTAAAGGTTAACATCATCATCAAGTACCCAGAGAAGTGCCAAAGAGAGGAAGATGGAAAGAGGCTGGTTCCATGGGAAAGGATTCCTCCTTGGCTTCATCCTCCACCTGCTGCTGCAAGTACCTTAAGATAAGAGCAAGAGCTGAGCAGACATGTAACTCCTGGGAAGCAGAGAAAACAGGCTAATATTTTTTATTCTGAGATAGTCAATGATTGGATGTTCGTTATGGTAAAAATGATGCTCGTGACACTGATGGCTTTGTACCTCTTCCTAGGATCCTAATATTTAGTTAACTCTTTTCTCTTCTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTACCCAGGCTAGAGTGCAGTGGCAATATCTCAGCCCATTGCAACCTTCACCTCCCAGGTTCAAACGATCTCATGCCTCA…

  5. Genomics as the Foundation of Systems Biology • “Omic”ization of Biotech • Genomics • Functional genomics • Proteomics • Functional proteomics • Cellomics • Metabolomics • Toxicogeneomics • Pharmacogenomics Integrate GENETIC and CELLULAR components to create BIOLOGICAL SYSTEMS acting in a broad SOCIAL context.

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