1 / 18

Photodynamic Therapy

Photodynamic Therapy. Phototherapy. The first who used the light: Egyptians, Indians, Chinese and Grecee 1815. Carvin 1822. Sniadecki 1903. D. N. Finsen: Nobel Prize. Photochemotherapy. Indians: Psoralea corylifolia Egyptians: Ammi majus. PDT history. 1900. Oscar Raab

lukas
Download Presentation

Photodynamic Therapy

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Photodynamic Therapy

  2. Phototherapy • The first who used the light: Egyptians, Indians, Chinese and Grecee • 1815. Carvin • 1822. Sniadecki • 1903. D. N. Finsen: Nobel Prize

  3. Photochemotherapy • Indians: Psoralea corylifolia • Egyptians: Ammi majus

  4. PDT history • 1900. Oscar Raab • 1905. H. von Tappeiner take in the PDT

  5. Hematoporphyrin 1841. Sherer 1867. Thudicum 1871. Hoppe- Seyler

  6. Hematoporphyrin • 1924. Policard • Auler and Banzer • Figge and co workers: photodiagnosis

  7. Why do some photosensitiziers localize selectively in tumors? • Tumors have a larger interstital volume than normal tissues • Tumors often contain a larger fraction of macrophages than normal tissues • Tumors have a leaky microvasculature • Tumors have poor lymphatic drainage • The extracellular ph is low in tumors • Tumors contain a relatively large amount of newly synthesized collagen • Tumor tissue contains many receptors for lipoproteins

  8. PDT treatment Use photosensitizing solution Collect in cancer Selective tumour collapse Irradiate

  9. Porfirin

  10. PDT mechanism Energy transport  reactive oxygen

  11. PDT mechanism Electron passing  free radical

  12. PDT mechanism photosensitizing Activation with light Introduce photosensitizing into the cell release reactive oxygen end free radical tissue necrosis or apoptozis

  13. Other tumour therapy Surgery disadvantage: - can’t remove total the cancer - matastasis Radio- and chemotherapy disadvantage: - to hight degree damage - resistance

  14. Photodynamic Therapy Advantage - selective destruction - not develop resistance Disadvantage - only use surface cancer - cell of small size

  15. Other field of application • Arteriosclerosis • Germ, virus inanctivation • Gum inflammation • Blood sterilization • Water purification

  16. Thank you for your patience

More Related