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Evaluation of topical dosage forms

Learn about the benefits and drawbacks of topical drug delivery systems, from avoiding first-pass metabolism to skin irritation risks. Understand the layers of skin and how topical dosage forms are evaluated using tools like the Brookfield viscometer.

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Evaluation of topical dosage forms

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  1. Evaluation of topical dosage forms DR. J. DOMENECH

  2. Topical delivery includes two basic types of product: • 1. External topicals that are spread, sprayed, or otherwise dispersed on to cutaneous tissues to cover the affected area. • 2. Internal topicals that are applied to the mucous membrane orally, vaginally  or on  anorectal tissues for local activity.

  3. Advantages of Topical Drug Delivery Systems • Avoidance of first pass metabolism. • Convenient and easy to apply. • Avoidance of  the risks and inconveniences of intravenous therapy and of the varied conditions of absorption, like pH changes, presence of enzymes, gastric emptying time etc. • Achievement of efficacy with lower total daily dosage of drug by continuous drug input. • Avoids fluctuation in drug levels, inter- and intrapatient variations.

  4. Ability to easily terminate the medications, when needed. • A  relatively large area of application in comparison with buccal or nasal cavity • Ability to deliver drug more selectively to a specific site. • Avoidance of gastro-intestinal incompatibility. • Providing utilization of drugs with short biological half-life, narrow therapeutic window. • Improving physiological and pharmacological response. • Improve patient compliance. • Provide suitability for self-medication.

  5. Disadvantages of Topical Drug Delivery Systems • Skin irritation of contact dermatitis  may  occur  due to the drug and/or excipients. • Poor permeability of some drugs  through  the  skin. • Possibility of allergenic reactions. • Can be used only for drugs which require very small plasma concentration for action • Enzyme in epidermis may denature the drugs • Drugs of larger particle size not easy to absorb through the skin

  6. The layers of skin

  7. The layers of epidermis • Stratum Germinativum (Growing Layer) • Malpighion Layer (pigment Layer) • Stratum Spinosum (Prickly cell Layer) • Stratum Granulosum (Granular Layer) • Stratum Lucidum • Stratum Corneum (Horny Layer)

  8. Evaluation Of Topical Dosage Form

  9. Evaluation Of Topical Dosage Form

  10. Evaluation Of Topical Dosage Form

  11. Evaluation Of Topical Dosage Form

  12. Evaluation Of Topical Dosage Form

  13. Evaluation Of Topical Dosage Form

  14. Evaluation Of Topical Dosage Form

  15. Evaluation Of Topical Dosage Form

  16. Evaluation Of Topical Dosage Form

  17. Evaluation Of Topical Dosage Form

  18. Brookfield viscometer(RVT)

  19. Evaluation Of Topical Dosage Form

  20. Thanks for your attention

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