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Cell Signaling. “Real Life” Cell Communication: Flight or Fight Response. While watching the movie clip, record at least TWO responses cells have to signals. . Pathways with Friends. Handout Diagram. Steps of Cell Signaling. Reception Signal Transduction Cellular Response. Reception.
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“Real Life” Cell Communication: Flight or Fight Response • While watching the movie clip, record at least TWO responses cells have to signals.
Pathways with Friends • Handout • Diagram
Steps of Cell Signaling • Reception • Signal Transduction • Cellular Response
Reception Online Simulation: http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&B Molecule the receptor binds to? Action of the receptor? • G-Protein • Tyrosine Kinase • Ligand-Gated Ion Channel • Intracellular Receptor
Signal Transduction Online Simulation: http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&C Receptor/s the messenger works with Action of the messenger Second Messengers a. Cyclic AMP b. Calcium ions c. Protein kinases
Cellular Responses Online Simulation: http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&D Examples • Testosterone (intracellular receptors) • Cholera, Viagra (cAMP secondary messengers) • Muscle Contraction (Ca2+ secondary messengers) • Cell Reproduction/Cancer (kinase messengers)
Cell Cycle Animations • Stages of the Cell Cycle 2) Mitosis Movie
Regulation of Mitosis • Cyclins - Their levels in the cell rise and fall with the stages of the cell cycle.
Cyclin-dependent kinases (Cdks) • G1 (Cdk4) • S-phase (Cdk2) • M-phase (Cdk1) • Levels in the cell remain fairly stable, but each must bind the appropriate cyclin (whose levels fluctuate) in order to be activated.
Anaphase-promoting complex (APC) or cyclosome (APC/C) • allows the sister chromatids to separate • degrades the mitotic cyclins
Role of Cyclin & Cdks • Protein kinase + Cyclin = Cdks (Cyclin Dependent Kinases) • Advance the cell at G1 and G2 stages • MPF is a type of Cdk + Cyclin
4. Cdk portion recycled 5. Cyclins build up and trigger mitosis again 3. Mitosis ends 2. Cyclin begins to degrade 1. MPF signals mitosis to begin
Cancer • HHMI Video Clip http://www.hhmi.org/biointeractive/cancer/lectures.html • p53 gene affects production of Cdk2 and apoptosis