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CONTROLLED SYNTHESIS OF NANOPARTICLES FOR INHALATION EXPOSURE STUDIES

Investigating engineered nanoparticles for potential health impacts through controlled production and exposure assessments in occupational environments. Research includes studying genotoxicity, inflammatory responses, and airway irritation.

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CONTROLLED SYNTHESIS OF NANOPARTICLES FOR INHALATION EXPOSURE STUDIES

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  1. CONTROLLED SYNTHESIS OF NANOPARTICLES FOR INHALATION EXPOSURE STUDIES M. MIETTINEN1, V. SUONMAA1, U. TAPPER2, U. BACKMAN2, J. JOUTSENSAARI1, A. AUVINEN2 and J.K. JOKINIEMI1,2 1Fine Particle and Aerosol Technology Laboratory, Department of Environmental Science, University of Kuopio, P.O.Box 1627, FI-70211 Kuopio, Finland 2Fine Particles, Technical Research Centre of Finland, P.O. Box 1000, 02044 VTT, Espoo, Finland NOSA Aerosol Symposium Helsingør, Denmark, 8.-9.11.2007 Mirella Miettinen M.Sc., Research Scientist

  2. BACKGROUND • Nanohealth research consortium • University of Kuopio • University of Helsinki • Finnish Institute of Occupational Health • Objectives • controlled production of engineered nanoparticles • exposure assessment in occupational environments • adverse effects of nanoparticles • airway irritation and changes in the respiratory patterns • inflammatory responses of the lungs and pulmonary cells • genotoxicity Mirella Miettinen M.Sc., Research Scientist

  3. EXPERIMENTAL SET-UP • flow reactor • Ti(C3H7O)4 liquid precursor in bubbler • N2 carrier gas • Ti(C3H7O)4 → TiO2 + 4C3H6 + 2H2O • dilution with dry and humified air • size distributions: SMPS (3071A DMA+3022A CPC) • gaseous byproducts: FTIR (GASMETTM) • mass concentration: filter samples (Teflon,Gelman) • TEM, XRD, BET heat Mirella Miettinen M.Sc., Research Scientist

  4. PC = pressure controller CO = critical orifice EXH = exhaust = heated line CO PC PC CO CO PC Qd2 p fabric filter EXH EXH Qd1 MFC Tb = bubbler temperature T2 = reactor temperature Qb = N2 flow through bubbler Qr = residence time N2 flow Qd = prim. dilution air flow Qd2 = secondary dilution air flow FTIR HEPA T T2 room air TEM EXPOSURE CHAMBER SMPS 12 slpm Qb Qr Tb Mirella Miettinen M.Sc., Research Scientist N2

  5. RESULTS: REACTOR T AND RESIDENCE TIME Mirella Miettinen M.Sc., Research Scientist

  6. T2 = 500 °C, Qr = 1.8 slpm T2 = 800 °C, Qr = 0.5 slpm Mirella Miettinen M.Sc., Research Scientist

  7. 3 T2 = 500 °C, Qr = 1.8 slpm ,) H2O RH(%) 40.1 C3H6 ppm 38.4 ppm 4.5 CO ppm 2.1 NOx 18.3 vol % O2 0 10 20 30 40 50 60 70 80 90 100 3 T2 = 800 °C, Qr = 0.5 slpm , H2O 46.7 RH(%) C3H6 ppm 14.7 ppm 23.2 CO 4.1 ppm CH4 19.4 vol % O2 0 10 20 30 40 50 60 70 80 90 100 Mirella Miettinen M.Sc., Research Scientist

  8. RESULTS: DILUTION RATIO Mirella Miettinen M.Sc., Research Scientist

  9. CONCLUSIONS AND FUTURE • Highly controlled nanoparticle generator • Adjustable and repeatable • Inhalation exposure experiments have just started • In future new materials: copper, cobalt Mirella Miettinen M.Sc., Research Scientist

  10. ACKNOWLEDGEMENTS This work was funded by the Academy of Finland (decision number 118114) in the FinNano research program Mirella Miettinen M.Sc., Research Scientist

  11. THANK YOUAND BON APPETIT! Mirella Miettinen M.Sc., Research Scientist

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