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Detecting and Treating Asparaginase-Related Toxicities in Acute Lymphoblastic Leukemia

Detecting and Treating Asparaginase-Related Toxicities in Acute Lymphoblastic Leukemia. Activity Goals. Acute Lymphoblastic Leukemia (ALL). Outcome: Adults vs Childhood ALL . PEG-asparaginase for Pediatric Patients. Retrospective Comparison of Adult vs Pediatric Protocols.

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Detecting and Treating Asparaginase-Related Toxicities in Acute Lymphoblastic Leukemia

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  1. Detecting and Treating Asparaginase-Related Toxicities in Acute Lymphoblastic Leukemia

  2. Activity Goals

  3. Acute Lymphoblastic Leukemia (ALL)

  4. Outcome: Adults vs Childhood ALL

  5. PEG-asparaginase for Pediatric Patients

  6. Retrospective Comparison of Adult vs Pediatric Protocols

  7. Comparison of Adverse Events During Induction

  8. Serum Asparaginase Concentrations

  9. Grades 2-4 PEG-asparaginase-Related Adverse Events in Adults

  10. PEG-asparaginase in Modified Pediatric Protocol

  11. PK of Dex and Asparaginase Activity

  12. Asparaginase Formulations and Half-life

  13. PEGylated Asparaginase

  14. Asparaginase

  15. Current Dosing of Asparaginase

  16. AEs From PEG-asparaginase From the CCG-Augmented Pediatric BFM Protocol

  17. Asparaginase Hypersensitivity

  18. AEs to PEG-asparaginase in Adults

  19. Thrombosis

  20. Antibodies to PEG-asparaginase

  21. Measuring Asparaginase Activity

  22. Monitoring Serum Asparaginase Activity

  23. Dosing Asparaginase based on Serum Levels

  24. Presence of Neutralizing Antibody: Switch to Erwinia Asparaginase

  25. Why Use Asparaginase?

  26. Using Pediatric-inspired Approaches in Adult ALL

  27. The Importance of Asparaginase for ALL

  28. Management of Asparaginase Toxicity in Adults

  29. Conclusions

  30. Abbreviations

  31. Abbreviations (cont)

  32. References

  33. References (cont)

  34. References (cont)

  35. References (cont)

  36. References (cont)

  37. References (cont)

  38. References (cont)

  39. References (cont)

  40. References (cont)

  41. References (cont)

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