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Monoclonal Antibodies in CVD: What Does the Future Hold?

Monoclonal Antibodies in CVD: What Does the Future Hold?. Goals. Monoclonal Antibodies: The Basics. Study of Monoclonal Antibodies in CVD. Gain-of-Function vs Loss-of-Function Mutations in PCSK9. The ARIC Study. Mechanism of Action.

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Monoclonal Antibodies in CVD: What Does the Future Hold?

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  1. Monoclonal Antibodies in CVD:What Does the Future Hold?

  2. Goals

  3. Monoclonal Antibodies: The Basics

  4. Study of Monoclonal Antibodies in CVD

  5. Gain-of-Function vs Loss-of-Function Mutations in PCSK9

  6. The ARIC Study

  7. Mechanism of Action

  8. Phase 2 Trial of AMG 145 in Patients With Hypercholesterolemia

  9. Phase 2 Trial of AMG 145: Selected Results

  10. Phase 2 Trial of REGN727/SAR236553 in Patients With Hypercholesterolemia

  11. Phase 2 Trial of REGN727/SAR236553: Selected Findings

  12. Statin Intolerance

  13. AEs in a Phase 2 Trial of AMG 145

  14. AEs in a Phase 2 Trial of AMG 145 (cont)

  15. AEs in a Phase 2 Trial of REGN727/ SAR236553

  16. AEs in a Phase 2 Trial of REGN727/ SAR236553 (cont)

  17. Potential Therapeutic Roles for PCSK9 Monoclonal Antibodies

  18. Phase 3 Trials: ODYSSEY Outcomes

  19. Phase 3 Trials: FOURIER Outcomes

  20. The Effects on Lipoprotein(a)

  21. Abbreviations

  22. Abbreviations (cont)

  23. References

  24. References (cont)

  25. References (cont)

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