1 / 16

Development of Cerebral Aneurysms. A Prediction Model

Development of Cerebral Aneurysms. A Prediction Model. Ihor Machyshyn. Supervisors. Dr. Ir. P.M.J. Rongen (Philips Medical Systems) Dr. Ir. A.A.F. van de Ven (TU/e, W&I) Dr. Ir. S.J.L. van Eijndhoven (TU/e, W&I) P rof. D r. I r. F.N. van de Vosse (TU/e, BMT)

maisie-mcknight
Download Presentation

Development of Cerebral Aneurysms. A Prediction Model

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Development of Cerebral Aneurysms. A Prediction Model Ihor Machyshyn Supervisors • Dr. Ir. P.M.J. Rongen (Philips Medical Systems) • Dr. Ir. A.A.F. van de Ven (TU/e, W&I) • Dr. Ir. S.J.L. van Eijndhoven (TU/e, W&I) • Prof. Dr. Ir. F.N. van de Vosse (TU/e, BMT) • Dr. Ir. P.H.M. Bovendeerd (TU/e, BMT)

  2. 3D Rotational Angiography (3D-RA) Combined X-ray images into a 3D view safe? dangerous?

  3. Approaches to assess risk of rupture • Current clinical practice (based on geometry) • Mechanical analysis: • Hemodynamical approach • Vessel wall mechanics • Stress and strain estimation • Adaptation of the tissue • Rupture criterion

  4. Goal of the project • Develop a model that uses realistic description of aneurysmal tissue • Study growth of cerebral aneurysms

  5. Blood Vessel Histology

  6. Model Variables Collagen - collagen stretch - recruitment - collagen thickness - attachment collagen stretch Elastin - elastin (tissue) stretch

  7. Equations Governing Mechanics • Constitutive equation: with • Equation of equilibrium: • Incompressibility equation:

  8. Evolution Equations of Remodeling • Equations of remodeling: with - rate constants of remodeling • Initial conditions

  9. Healthy State of an Artery

  10. Transition between States

  11. Remodeling to a Healthy State

  12. Visualization of Instability

  13. Stability of Equilibrium ((e)) States

  14. Analysis of Stability of an Equilibrium State of a Thin-walled cylinder. Equations where

  15. Method satisfy equations on the previous slide Stability condition:

  16. Result

More Related