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UADT cancers

UADT cancers. Interim results. The combined organs and tissues of the respiratory tract and the upper part of the digestive tract (including the lips, mouth, tongue, nose, throat, vocal cords, and part of the esophagus and windpipe). Search strategy.

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UADT cancers

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  1. UADT cancers Interim results

  2. The combined organs and tissues of the respiratory tract and the upper part of the digestive tract (including the lips, mouth, tongue, nose, throat, vocal cords, and part of the esophagus and windpipe).

  3. Search strategy • “Nasopharynx” OR “nasopharyngeal” OR “NPC” OR “Oropharynx” OR “oropharyngeal” OR “Hypopharynx” OR “hypopharyngeal” OR “pharynx” OR “larynx” OR “laryngeal” OR “paranasal” OR “head and neck” OR “UADT” OR “aerodigestive” OR “upper respiratory” OR “ENT” OR “otorhinolaryngologic*” • Cancer OR cancers OR carcinoma OR carcinomata OR neoplasm OR neoplasms OR tumor OR tumors OR tumour OR tumours  • "IAP" OR "Indoor air" OR "pollution" OR "pollutant" OR "fuel" OR "fuels" OR "dung" OR "agricultural waste" OR "crop waste" OR "crop residue" OR "charcoal" OR "coal" OR "biomass" OR "wood" OR "stove" OR "stoves" OR "chula" OR "chulla" OR "oven" OR "ovens" OR "smoke" OR "smoky" OR heat* OR cook* OR light* OR burn*

  4. Databases • PubMed (Medline) • Embase (Scopus & Ovid) • Cochrane Controlled Trials Register • CINAHL (Ovid) • Global Health (Ovid) • DARE (Database of Abstracts of Reviews of Effects) – for reviews • LILACS (Latin American and Caribbean literature) • Scielo • Index Medicus Africanus • Chinese databases CNKI – by Ray Liu @UCB

  5. Search results (English) • 11,627 search results • 703 abstracts screened • 55 full papers reviewed • 9 papers with relevant data • Did not capture all references from IARC monograph – 2 or 3 additional papers • Need to cross-check references and citations plus await results from Chinese databases

  6. 9 studies • 3 China, 1 Singapore, 1 Malaysia, 2 India, 1 Germany, 1 Brazil • 1 kerosene exposure only (not for M/A) • 2 insufficient data for M/A Armstrong 1983, Shanmugaratnam 2000

  7. Outcomes

  8. Exposure assessment

  9. Quality issues

  10. All studies (n=6)

  11. Publication Bias • Begg's Test • adj. Kendall's Score (P-Q) = 20 • Std. Dev. of Score = 14.58 • Number of Studies = 12 • z = 1.37 • Pr > |z| = 0.170 • z = 1.30 (continuity corrected) • Pr > |z| = 0.193 (continuity corrected) • Egger's test • ------------------------------------------------------------------------------ • Std_Eff | Coef. Std. Err. t P>|t| [95% Conf. Interval] • -------------+---------------------------------------------------------- • -------------+------ • slope | .0139528 .2934942 0.05 0.963 -.6399932 .6678987 • bias | 2.185734 1.016875 2.15 0.057 -.0800038 4.451472 • ------------------------------------------------------------------------------

  12. NPC (n=2)

  13. NPC plus nasal cavity/middle ear n=3

  14. Excluding nasopharynx (n=3)

  15. Key assumptions/issues • Heterogeneous outcomes • Combine fuel categories • Fossil fuel stoves • Unclear reference categories • Ever wood vs. never wood • Cooking as exposure when most of subjects are men

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