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CHMI 2227E Biochemistry I

CHMI 2227E Biochemistry I. Proteins: Quaternary structure. Quaternary structure. hydrophobic. hydrophilic. Porin: a trimeric membrane-bound protein. Quaternary structure. Quaternary structure Hemoglobin. HbA. Myoglobin. Quaternary structure Hemoglobin HbA vs myoglobin.

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CHMI 2227E Biochemistry I

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  1. CHMI 2227EBiochemistry I Proteins: Quaternary structure CHMI 2227 - E.R. Gauthier, Ph.D.

  2. Quaternary structure CHMI 2227 - E.R. Gauthier, Ph.D.

  3. hydrophobic hydrophilic Porin: a trimeric membrane-bound protein Quaternary structure CHMI 2227 - E.R. Gauthier, Ph.D.

  4. Quaternary structureHemoglobin CHMI 2227 - E.R. Gauthier, Ph.D.

  5. HbA Myoglobin Quaternary structureHemoglobin HbA vs myoglobin CHMI 2227 - E.R. Gauthier, Ph.D.

  6. Quaternary structureOxygen binding by Hb and myoglobin CHMI 2227 - E.R. Gauthier, Ph.D.

  7. Quaternary structureOxygen binding by Hb and myoHb CHMI 2227 - E.R. Gauthier, Ph.D.

  8. B A Quaternary structureOxygen binding by Hb and myoHb CHMI 2227 - E.R. Gauthier, Ph.D.

  9. B A Quaternary structureOxygen binding by Hb and myoHb CHMI 2227 - E.R. Gauthier, Ph.D.

  10. Quaternary structureO2 binding changes the 3-D shape of Hb CHMI 2227 - E.R. Gauthier, Ph.D.

  11. Quaternary structureO2 binding changes the 3-D shape of Hb CHMI 2227 - E.R. Gauthier, Ph.D. http://upload.wikimedia.org/wikipedia/commons/0/07/Hb-animation2.gif

  12. O2 O2 O2 O2 O2 O2 O2 O2 O2 O2 O2 O2 O2 O2 Low affinity High affinity Saturated Quaternary structureHb is an allosteric protein CHMI 2227 - E.R. Gauthier, Ph.D.

  13. Quaternary structureWhy Hb is allosteric, while Myoglobin is not? CHMI 2227 - E.R. Gauthier, Ph.D.

  14. The Bohr effect http://www.aw-bc.com/mathews/ch07/fi7p16.htm CHMI 2227 - E.R. Gauthier, Ph.D.

  15. Gas exchangeIn the tissues Glucose + O2 CO2 H2O Carbonic anhydrase CO2 H2CO3 Hb-4O2 H2O + Cl- HCO3- HCO3- (to lungs) H+ ATP Hb-H+ 4O2 4O2 Plasma Erythrocytes Tissues CHMI 2227 - E.R. Gauthier, Ph.D.

  16. Gas exchangeIn the lungs CO2 CO2 CO2 H2O Carbonic anhydrase H2CO3 Air Hb-4O2 H2O + Cl- HCO3- HCO3- H+ Hb-H+ 4O2 O2 O2 Plasma Erythrocytes Lungs CHMI 2227 - E.R. Gauthier, Ph.D.

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