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Cell to Cell Communication

Cell to Cell Communication. John Ireland. Cell Signaling Overview. Exterior of Cell. Interior of Cell. Cellular Response. Membrane Receptor. Signal Transduction Pathway. Intracellular Receptor. Types of Cell-Cell Signaling. Direct Contact. Paracine Signaling. Endocrine Signaling.

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Cell to Cell Communication

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  1. Cell to Cell Communication John Ireland

  2. Cell Signaling Overview Exterior of Cell Interior of Cell Cellular Response Membrane Receptor Signal Transduction Pathway Intracellular Receptor

  3. Types of Cell-Cell Signaling

  4. Direct Contact

  5. Paracine Signaling

  6. Endocrine Signaling

  7. Synaptic Signaling

  8. How does signaling happen?

  9. Phosphorylation Activated Protein Unactivated Protein

  10. Phosphorylation actives Proteins

  11. Phosphates are added to amino acids.

  12. Specifically either Serine/Threonine or Tyrosine

  13. Phosphates are added by Protein Kinases (specific enzymes)

  14. Dephosphorylation by Phosphotases deactivate the proteins

  15. Types of Receptors in Cells

  16. Intracellular

  17. Chemically Gated Ion Channels

  18. Enzymatic

  19. G-Protein Coupled

  20. Intracellular Receptors

  21. Triggered by Hydrophobic Ligands (i.e. Hormones)

  22. Complex Proteins with Multiple Domains.

  23. Blocked by an Inhibitor till Activation

  24. Mechanism Exterior Nucleus Cytoplasm Receptor w/ Inhibitor Hormone Gene Activation Inhibitor

  25. Protein Kinase Receptors

  26. Binding of external ligands causes internal phosphorylation

  27. Phosphorylation actives adapter proteins

  28. Adapter Proteins activate response.

  29. Insulin Receptor Mechanism Exterior Cytoplasm Insulin Response Protein Glucose Glycogen Synthase Insulin Receptor Insulin Glycogen

  30. G-Protein Coupled Receptor

  31. cAMP Signal Pathway Exterior Adenylate Cyclase GPCR G Protein Α Subunit w/ GTP (active) G Protein w/ GDP (inactive) ATP cAMP Cytoplasm

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