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Lipoprotein metabolism ط      Classification and functions of lipoproteins and Apoproteins

Lipoprotein metabolism ط      Classification and functions of lipoproteins and Apoproteins ط      Metabolism and degradation of Chylomicrons, VLDL ط      Metabolism and uptake of LDL ط      HDL metabolism ط      Apoproteins, Diseased state                                    D4 378-81 .

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Lipoprotein metabolism ط      Classification and functions of lipoproteins and Apoproteins

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  1. Lipoprotein metabolism ط     Classification and functions of lipoproteins and Apoproteins ط     Metabolism and degradation of Chylomicrons, VLDL ط     Metabolism and uptake of LDL ط     HDL metabolism ط     Apoproteins, Diseased state                                    D4 378-81 

  2. Inter-organ Transport of lipids ·         Table, Lipid-base energy is transported in bld by: chylom (diet), other LP (biosynth), alb (diet/degrad) and KB (β-FAOxid) a)       LP are synth in intestine & liver with a heterogeneous group of lipid-prt multi-complex b)       LP composed of various lipids & apoproteins held together by non-covalent force c)       LP carry varying proportions of energy considering metabolic & physiological state ·         Table, Apolipoproteins: a)       Modify enz activity (activate/inhibit) during lipid exchange b)       Specific recognition site (legand) for cell surface receptors (endocytosis)

  3. Table: Plasma Lipoproteins

  4. Table: Apolipoproteins

  5. 1.       fig, Chylomicrone Metabolism: Necent Chylom (intest/lymph) => Chylom (capillaries LPL) => Chylom Reminant => LIVER

  6. 2.       fig, VLDL Metabolism: VLDL (liver) => IDL (capillaries LPL) => LDL (capillaries LPL) => LIVER / MUSCLE

  7. 3.       fig, HDL Metabolism: Necent HDL-LCAT (intest / liver) => HDL3-LCAT (muscle & AT) => HDL2-LCAT (capillaries LPL) => LIVER

  8. Clinical Correlation of Lipid-Transportcc.9.3 • Disease cause high plasma TG, Chol (Hyperlipidemia) • 1.        lack of serum alb (analbuniemia) lead to increase in plasma TG • 2.        absence of LPL lead to deposit of diet fat in skin (eruptive xanthemas): treated by low fat diet • 3.        defect in Apo-B (neuropathy, red cell deformity) • o        lead to defect in chylom & VLDL transport (β-lipoproteinemia) • o        cause deficiency of fat absorption from diet

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