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Genetics: Multiple Alleles. Biology 12. Joke of the day:. Multiple Alleles. Many genes have more than two alleles An individual does not have more than two alleles for each trait but different individuals can have different pairs of alleles when multiple alleles exist.
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Genetics: Multiple Alleles Biology 12
Multiple Alleles • Many genes have more than two alleles • An individual does not have more than two alleles for each trait but different individuals can have different pairs of alleles when multiple alleles exist
Example: Multiple Alleles • Human blood type is controlled by three alleles : IA, IB and i. • Alleles IA and IB are dominant over i • IA and IB are codominant
IAi IAi IBi IBi Problem: Multiple Alleles • Show the cross between a mother who has type O blood and a father who has type AB blood. i i GENOTYPES: - IAi (2) IBi (2) - ratio 1:1 IA IB PHENOTYPES: • type A blood (2); type B • blood(2) • - ratio 1:1
IBi IAIB IAi ii Problem2: Multiple Alleles • Show the cross between a mother who is heterozygous for type B blood and a father who is heterozygous for type A blood. GENOTYPES: IA i • IAIB (1); IBi (1); • IAi (1); ii (1) • - ratio 1:1:1:1 IB i PHENOTYPES: • type AB (1); type B (1) • type A (1); type O (1) • - ratio 1:1:1:1
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The Rhesus factor, also known as the Rh factor, gets its name from experiments conducted in 1937 by scientists Karl Landsteiner and Alexander S. Weiner. Involved Rabbits which when injected with the Rhesus monkey’s red blood cells, produced an antigen present in the red blood cells of many humans Rhesus Factor http://content9.clipmarks.com/blog_cache/latimesblogs.latimes.com/img/E0C83714-56E5-4757-B9F1-604FCE5643C3
Rhesus Factor: • The Rhesus factor is an antigen (a protein) that exists on the surface of red blood cells. • If a person has either two (+) genes for Rh or one (+) and one (-) Rh gene, they will test Rh(+). • A person will be negative only if they have 2 (-).
Relevance of Rh Factor & ABO Typing? • It is very important in terms of babies • Example: An Rh(-) mother has a Rh (+) baby, she will make antibody against the Rh(+) fetus
To do: • Blood type WS • Genetics: Multiple Allele Traits WS