10 likes | 96 Views
The Crash !!!! HIV-The Silent Killer Sanjukta Hota Alexandria Randriamahefa Arlin Toro. LOGO. LOGO. Subject 12 -visit 5. RESULTS Subject 1. BACKGROUND. CD4+ count Healthy person 800-1,200/mm 3 of blood AIDS <200/mm 3 of blood. HYPOTHESIS.
E N D
The Crash!!!!HIV-The Silent Killer • SanjuktaHota • Alexandria Randriamahefa • ArlinToro LOGO LOGO Subject 12 -visit 5 RESULTS Subject 1 BACKGROUND • CD4+ count • Healthy person 800-1,200/mm3 of blood • AIDS <200/mm3 of blood HYPOTHESIS Data from Markham, et al. 1998GP-120 sequence data GP-120 CD$ Antibody RESULTS Subject 15 CONCLUSIONS Drasticdecline in CD4+ counts are caused by the mutations in the GP-120 gene. When comparing the subjects 1 and 15 with drastic decline in CD4 counts with the non progressor, they have a substitution of Aspartic acid (D) to Asparagine (N) in the 280th position of the amino acid sequence. MATERIALS AND METHODS BIBLIOGRAPHY Bioquest HIV Problem Set Protein Data Bank Swiss-Pdb Viewer Biology Workbench Microbes Coutnt Markham, et al., 1998 Data Set Protein Data Bank Swiss-Pdb Viewer Biology Workbench