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Mathematics and Post-Genomic Biology

Mathematics and Post-Genomic Biology. Biology has changed. Biology is on the popular mind more than chemistry & physics these days Students don’t choose to study biology because they “like science but not the math” anymore. Growth of PDB. Data Poor → Data Rich.

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Mathematics and Post-Genomic Biology

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  1. Mathematics and Post-Genomic Biology

  2. Biology has changed • Biology is on the popular mind more than chemistry & physics these days • Students don’t choose to study biology because they “like science but not the math” anymore...

  3. Growth of PDB Data Poor → Data Rich • Not long ago, it could take a lifetime to gather even a small dataset relevant to understanding a living system…

  4. Post-Genomic Instruments Expression array “chips” 15,000+ genes/chip at $500/chip (and falling!) • High throughput SNP genotyping automation • $0.01/SNP and dropping fast • LC/MS/MS proteomics • Gigabyte / day of spectra!

  5. Biology’s “New Math” • Calculus matters, but less than in physics or chemistry… • Discrete math has a dramatically more important role, e.g. in sequence analysis and genetics • Due to its less “law-like” nature, understanding statistical inference is a critical basic skill for nearly all biology

  6. Lots of REAL data available free on the web • Students can do REAL scientific projects www.rcsb.org/pdbmetacyc.orgwww.uchsc.edu/sm/chs

  7. Great Web Resources

  8. New relevance opportunities • Based on news stories • Gene discoveries • Crime / DNA identification • Epidemics • Related to teen concerns • Genetics and sports / beauty • HIV / AIDS • Drugs, alcohol & tobacco http://www.gmathletes.net/

  9. Graphs & Cycles • Molecular biology is inherently network-y • Metabolism, Signaling and Regulatory networks • Functional/Semantic links • Evolutionary relationships • Other levels, too • Global carbon cycles • Neurons & synapses

  10. Genomic Combinations Humans have 40,877 proteins (a total of 18,311,133 amino acids); If the 20 characters are randomly distributed, what is the probabilityof seeing any particular 4 letter sequence? An 11 letter one?

  11. Drugs and Receptors HIV protease boundto Ritonavir • Geometry of interactions • Receptor bindingand pharmacodynamics • Drug trials, safety anddata interpretation http://www.mc.uky.edu/pharmacology/instruction/pha824mp

  12. Teamwork • Team science is growing in importance. Teams can work in teaching, too. • Coordination betweenteachers of math and biology • Studentteams doing complementary problems • Researcher / industry partnerships with schools,students and teachers http://www.succcessstories.com

  13. You have a critical role! • Good jobs are available for people with math and biology skills, at all levels • Health care, especially nursing • Biotech industry • Pharmaceuticals & pharmacists • Math/bio is an increasingly important competence for consumers & citizens • Informed patients get better health care • Public debates on epidemics, genetic modifications, etc.

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