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Applied Developmental Biology Dr. Lubna Tahtamouni The Hashemite University 23/2/2009 Week # 3

Applied Developmental Biology Dr. Lubna Tahtamouni The Hashemite University 23/2/2009 Week # 3 Spermatogenesis. 1. Gametogenesis: Spermatogenesis + Oogenesis. A. Spermatogenesis. Male Reproductive System. Production of: Semen Hormones. Semen. 5% Sperm

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Applied Developmental Biology Dr. Lubna Tahtamouni The Hashemite University 23/2/2009 Week # 3

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  1. Applied Developmental Biology Dr. Lubna Tahtamouni The Hashemite University 23/2/2009 Week # 3 Spermatogenesis 1

  2. Gametogenesis: Spermatogenesis + Oogenesis

  3. A. Spermatogenesis

  4. Male Reproductive System • Production of: • Semen • Hormones

  5. Semen • 5% Sperm • 2. 65% Secretions of seminal vesicles: • proteins, enzymes, mucus, fructose, prostaglandins • 3. 30% secretions of prostate glands: • milky alkaline fluid, high in basic sugars, pH ~ 7.3-8

  6. Testis: Groups of Seminiferous Tubules

  7. Cross Section through Testis • Cells in spermatogenesis: • Spermatogenic cells • Sertoli cells • Leydig cells

  8. Sertoli cells

  9. prominent euchromatic nucleus and prominent nucleolus- cell sends processes around developing germ cells making cell margins difficult to • observe at LM level • inter-Sertoli cell tight junctions at the base of the tubule form blood testis barrier • - synthesizes and secretes a fluid into the lumen containing: • 1. androgen binding protein (ABP) that binds testosterone and creates increased (total) • concentration of testosterone • - secretion of ABP stimulated by FSH and testosterone • 2. inhibin that suppresses FSH secretion from pituitary • provides environment for germ cell development (nurse cell) • phagocytose and digest shed residual bodies produced by developing germ cells

  10. interstitial cells of Leydig (Leydig cells): - steroid-synthesizing cell with enriched sER and mitochondria- produce and secrete testosterone- stimulated by LH and prolactin from pituitary

  11. Seminiferous Tubule

  12. Spermatogenesis

  13. Spermatogenesis

  14. Spermatogenesis Spermatocytogenesis Meiosis Spermiogenesis

  15. Spermiogenesis

  16. The shape of a human sperm cell is adapted to its function Middlepiece Neck Head Plasma membrane Tail Mitochondrion(spiral shape) Nucleus Acrosome

  17. Cross Section through the Tail

  18. Hormonal Regulation of Spermatogenesis

  19. Semen value Volume Concentration Motility Morphology Normal range > 2.0ml > 20 million/ml > 40% motile >14% Semen Analysis – reference values

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