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Addressing Hypnotic medicines use in primary care . National Prescribing Service . Presented by Joyce McSwan Accredited Consultant Pharmacist. Insomnia in Primary Care. 95%. 80%. What Insomnia is not. 3 Ds of Insomnia . D ifficulty falling asleep D ifficulty staying asleep OR
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Addressing Hypnotic medicines use in primary care National Prescribing Service Presented by Joyce McSwan Accredited Consultant Pharmacist
Insomnia in Primary Care 95% 80%
3 Ds of Insomnia • Difficulty falling asleep • Difficulty staying asleep OR • Day time distress (associated with non refreshing sleep)
1. Identify and manage contributing factors first Medications Behavioural Substance Use Insomnia Complaint Circadian rhythm disorder Psychiatric Disorder Situational Environmental Primary sleep disorder Medical condition
1a. Offer non-drug therapies for insomnia • Benefits: • Persistent sleep improvements after therapy • Reduced potential for harms • No risk of drug dependence
Most evidence - Behavioural and cognitive therapies • In 4-8 weeks, • Fall asleep faster (23 mins vs 14 mins earlier) • Reduce their time awake (30 mins after sleep onset) • Improvement up to 2 years • > 55 yo • Hypnotic medicines do not provide this long-term benefit
AVOID Diazepam Flunitrazepam Nitrazepam
2b. Hypnotics in the Elderly • Meta analysis – • NNT 13>60 yo for 1 month to improve sleep • NNT 6causing adverse effect - fatigue, cognitive impairment, serious events following falls, fractures and MVA
3. Stepped care approach to stopping hypnotic medicines • Simple strategies may start the ball rolling. • Lack of evidence for adjunctive therapy in place of hypnotics. • 1/3 have trouble stopping • Gradual dose reduction may still be required after short-term use • Minimise Rebound insomnia
Tapering dose gradually on an individual basis (8-12 weeks) • Time in between dose reductions (several days) • Reduce by 10-20% / week • Change to equivalent diazepam then reduce dose • Reduce one benzodiazpine at a time.
One size does not fit all.... • Hypnotic medicines may be acceptable for: • Chronic use: • No adverse effects • Sleeping well • Aware about unintentional dependence • Attempts have been made to stop but refused or unsuccessful • Combination with non-drug therapy might reduce hypnotic dose • Review regularly
Other NPS resources: • NPS News 67, 2010 – Addressing hypnotic medicines use in primary care • NPS Prescribing Practice Review 49: Management options for improving sleep • Clinical audit: Use of benzodiazepines, zolpidem and zopiclone in insomnia • For Patients : Reduction plan for your sleeping tablets • Case study 62: Maximising sleep and minimising potential harms
Good Night and Sweet dreams