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Prolactin in Mammals

Prolactin in Mammals. By: Megan the epic M, Erica the fried squid pickel , Abby, Alyssa, Katie, Hiba. Gland. Prolactin is produced in the pituitary gland in response to pregnancy and nursing. Base. Peptide-based It is a pituitary polypeptide Alpha helix folded. Pathway/Mechanism.

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Prolactin in Mammals

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  1. Prolactin in Mammals By: Megan the epic M, Erica the fried squid pickel, Abby, Alyssa, Katie, Hiba

  2. Gland • Prolactin is produced in the pituitary gland in response to pregnancy and nursing.

  3. Base • Peptide-based • It is a pituitary polypeptide • Alpha helix folded

  4. Pathway/Mechanism • Peptide hormone binds to a receptor on the outside of the cell membrane which activates the Jak2 kinase. Stat5, a transcription factor, is activated by Jak2. Stat5 then goes into the nucleus and hooks onto the DNA triggering a cellular response.

  5. Prolactin’s Cellular Response • Differentiation of the mammary gland which causes the production of the milk proteins. • WAP- encodes for milk proteins • BLG- encodes for milk proteins • Casein- encodes for milk proteins

  6. Negative Feedback Loop • Suckling is the major stimulus of prolactin production • Thyrotropin-releasing factor stimulated by hypothalamus. • TRH is sent to pituitary gland • Pituitary gland releases prolactin • Prolactin stimulates milk production in breasts beginning in late pregnancy and sustained after birth. • When the mother no longer needs to produce milk, dopamine inhibits prolactin by signaling the hypothalamus to stop.

  7. Altering pathway • In malignant tissues prolactin fails to trigger, differentiation, and instead enhances breast epithelial survival and motility. • Prolactin, when over-expressed, inhibits apoptosis in cervical cancer cells

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